@article{fdi:010075218,
  title = {{C}ross-species immune recognition between {P}lasmodium vivax {D}uffy binding protein antibodies and the {P}lasmodium falciparum surface antigen {VAR}2{CSA}},
  author = {{G}nidehou, {S}. and {M}itran, {C}. {J}. and {A}rango, {E}. and {B}anman, {S}. and {M}ena, {A}. and {M}edawar, {E}. and {L}ima, {B}. {A}. {S}. and {D}oritchamou, {J}. and {R}ajwani, {J}. and {J}in, {A}. and {G}avina, {K}. and {N}tumngia, {F}. and {D}uffy, {P}. and {N}arum, {D}. and {T}uikue {N}dam, {N}icaise and {N}ielsen, {M}. {A}. and {S}alanti, {A}. and {K}ano, {F}. {S}. and {C}arvalho, {L}. {H}. and {A}dams, {J}. {H}. and {M}aestre, {A}. and {G}ood, {M}. {F}. and {Y}anow, {S}. {K}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground. {I}n pregnancy, {P}lasmodium falciparum parasites express the surface antigen {VAR}2{CSA}, which mediates adherence of red blood cells to chondroitin sulfate {A} ({CSA}) in the placenta. {VAR}2{CSA} antibodies are generally acquired during infection in pregnancy and are associated with protection from placental malaria. {W}e observed previously that men and children in {C}olombia also had antibodies to {VAR}2{CSA}, but the origin of these antibodies was unknown. {H}ere, we tested whether infection with {P}lasmodium vivax is an alternative mechanism of acquisition of {VAR}2{CSA} antibodies. {M}ethods. {W}e analyzed sera from nonpregnant {C}olombians and {B}razilians exposed to {P}. vivax and monoclonal antibodies raised against {P}. vivax {D}uffy binding protein ({P}v{DBP}). {C}ross-reactivity to {VAR}2{CSA} was characterized by enzyme-linked immunosorbent assay, immunofluorescence assay, and flow cytometry, and antibodies were tested for inhibition of parasite binding to {CSA}. {R}esults. {O}ver 50% of individuals had antibodies that recognized {VAR}2{CSA}. {A}ffinity-purified {P}v{DBP} human antibodies and a {P}v{DBP} monoclonal antibody recognized {VAR}2{CSA}, showing that {P}v{DBP} can give rise to cross-reactive antibodies. {I}mportantly, the monoclonal antibody inhibited parasite binding to {CSA}, which is the primary in vitro correlate of protection from placental malaria. {C}onclusions. {T}hese data suggest that {P}v{DBP} induces antibodies that functionally recognize {VAR}2{CSA}, revealing a novel mechanism of cross-species immune recognition to falciparum malaria.},
  keywords = {{V}ivax ; falciparum ; pregnancy ; {P}v{DBP} ; {VAR}2{CSA} ; immunity ; placental ; malaria ; {COLOMBIE} ; {BRESIL}},
  booktitle = {},
  journal = {{J}ournal of {I}nfectious {D}iseases},
  volume = {219},
  numero = {1},
  pages = {110--120},
  ISSN = {0022-1899},
  year = {2019},
  DOI = {10.1093/infdis/jiy467},
  URL = {https://www.documentation.ird.fr/hor/fdi:010075218},
}