@article{fdi:010075190,
  title = {{I}mplications of insecticide resistance for malaria vector control with long-lasting insecticidal nets: evidence from health facility data from {B}enin},
  author = {{T}okponnon, {F}. {T}. and {S}issinto, {Y}. and {O}gouyemi, {A}. {H}. and {A}deothy, {A}. {A}. and {A}dechoubou, {A}. and {H}ouansou, {T}. and {O}ke, {M}. and {K}inde-{G}azard, {D}. and {M}assougbodji, {A}. and {A}kogbeto, {M}. {C}. and {C}orn{\'e}lie, {S}ylvie and {C}orbel, {V}incent and {K}nox, {T}. {B}. and {M}nzava, {A}. {P}. and {D}onnelly, {M}. {J}. and {K}leinschmidt, {I}. and {B}radley, {J}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground{I}nsecticide-based interventions have averted more than 500 million malaria cases since 2000, but insecticide resistance in mosquitoes could bring about a rebound in disease and mortality. {T}his study investigated whether insecticide resistance was associated with increased incidence of clinical malaria.{M}ethods{I}n an area of southern {B}enin with insecticide resistance and high use of insecticide-treated nets ({ITN}s), malaria morbidity and insecticide resistance were measured simultaneously in 30 clusters (villages or collections of villages) multiple times over the course of 2years. {I}nsecticide resistance frequencies were measured using the standard {W}orld {H}ealth {O}rganization bioassay test. {M}alaria morbidity was measured by cases recorded at health facilities both in the whole population using routinely collected data and in a passively followed cohort of children under 5years old.{R}esults{T}here was no evidence that incidence of malaria from routinely collected data was higher in clusters with resistance frequencies above the median, either in children aged under 5 ({RR}=1.27 (95% {CI} 0.81-2.00) p=0.276) or in individuals aged 5 or over ({RR}=1.74 (95% {CI} 0.91-3.34) p=0.093). {T}here was also no evidence that incidence was higher in clusters with resistance frequencies above the median in the passively followed cohort ({RR}=1.11 (0.52-2.35) p=0.777).{C}onclusions{T}his study found no association between frequency of resistance and incidence of clinical malaria in an area where {ITN}s are the principal form of vector control. {T}his may be because, as other studies have shown, {ITN}s continue to offer some protection from malaria even in the presence of insecticide resistance. {I}rrespective of resistance, nets provide only partial protection so the development of improved or supplementary vector control tools is required to reduce {A}frica's unacceptably high malaria burden.},
  keywords = {{M}alaria ; {I}nsecticide ; {P}yrethroid ; {R}esistance ; {V}ector ; {BENIN}},
  booktitle = {},
  journal = {{M}alaria {J}ournal},
  volume = {18},
  numero = {},
  pages = {art. 37 [9 p.]},
  ISSN = {1475-2875},
  year = {2019},
  DOI = {10.1186/s12936-019-2656-7},
  URL = {https://www.documentation.ird.fr/hor/fdi:010075190},
}