Barakat F. auteur aut IRD Vansteelandt M. auteur aut IRD Triastuti A. auteur aut IRD Jargeat P. auteur aut IRD Jacquemin D. auteur aut IRD Graton J. auteur aut IRD Mejia K. auteur aut IRD Cabanillas B. auteur aut IRD Vendier L. auteur aut IRD Stigliani J. L. auteur aut IRD Haddad Mohamed auteur aut IRD Fabre N. auteur aut IRD text journalArticle eng text/pdf born digital access Three thiodiketopiperazines, botryosulfuranols A-C (1-3) were isolated from the endophytic fungus Botryosphaeria mamane. The three compounds present sulfur atoms on alpha- and beta-positions of phenylalanine derived residues and unprecedented two spirocyclic centers at C-4 and C-2'. Their planar structures were determined by spectroscopic analysis and absolute configurations were achieved by X-ray diffraction analysis and ECD and NMR chemical shifts calculations. Botryosulfuranol A (1) was the most cytotoxic compound against four cancer cell lines (HT-29, HepG2, Caco-2, HeLa) and two healthy cell lines (IEC6, Vero) highlighting the importance of an electrophilic center for cell growth inhibition. specialized Botryosphaeria mamane DE Gardner (Botryosphaeriaceae) Bixa orellana L. (Bixaceae) Thiodiketopiperazine Cytotoxic activity PEROU 076 020 084 158 142-148 2019 0031-9422 https://www.documentation.ird.fr/hor/fdi:010074948 10.1016/j.phytochem.2018.11.007 0031-9422 [F B010074948] https://www.documentation.ird.fr/hor/fdi:010074948 https://www.documentation.ird.fr/intranet/publi/2019/02/010074948.pdf Accès réservé (Intranet de l'IRD) IRD - Base Horizon / Pleins textes 2019-03-06 2025-02-24 fdi:010074948 fre