Horizon 1 1 17 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES Phytochemistry 142-148 Botryosphaeria mamane DE Gardner (Botryosphaeriaceae) Bixa orellana L. (Bixaceae) Thiodiketopiperazine Cytotoxic activity PEROU 2019 fdi:010074948 ENG Phytochemistry 0031-9422 ISI:000456755200018 10.1016/j.phytochem.2018.11.007 https://www.documentation.ird.fr/hor/fdi:010074948 https://www.documentation.ird.fr/intranet/publi/2019/02/010074948.pdf 158 Horizon (IRD) Three thiodiketopiperazines, botryosulfuranols A-C (1-3) were isolated from the endophytic fungus Botryosphaeria mamane. The three compounds present sulfur atoms on alpha- and beta-positions of phenylalanine derived residues and unprecedented two spirocyclic centers at C-4 and C-2'. Their planar structures were determined by spectroscopic analysis and absolute configurations were achieved by X-ray diffraction analysis and ECD and NMR chemical shifts calculations. Botryosulfuranol A (1) was the most cytotoxic compound against four cancer cell lines (HT-29, HepG2, Caco-2, HeLa) and two healthy cell lines (IEC6, Vero) highlighting the importance of an electrophilic center for cell growth inhibition. 076 ; 020 ; 084 UR152 / UR253 Pérou