@article{fdi:010074930,
  title = {{M}ajor microbiota dysbiosis in severe obesity : fate after bariatric surgery},
  author = {{A}ron-{W}isnewsky, {J}. and {P}rifti, {E}. and {B}elda, {E}. and {I}chou, {F}. and {K}ayser, {B}. {D}. and {D}ao, {M}. {C}. and {V}erger, {E}ric and {H}edjazi, {L}. and {B}ouillot, {J}. {L}. and {C}hevallier, {J}. {M}. and {P}ons, {N}. and {L}e {C}hatelier, {E}. and {L}evenez, {F}. and {E}hrlich, {S}. {D}. and {D}ore, {J}. and {Z}ucker, {J}ean-{D}aniel and {C}lement, {K}.},
  editor = {},
  language = {{ENG}},
  abstract = {{O}bjectives {D}ecreased gut microbial gene richness ({MGR}) and compositional changes are associated with adverse metabolism in overweight or moderate obesity, but lack characterisation in severe obesity. {B}ariatric surgery ({BS}) improves metabolism and inflammation in severe obesity and is associated with gut microbiota modifications. {H}ere, we characterised severe obesity-associated dysbiosis (ie, {MGR}, microbiota composition and functional characteristics) and assessed whether {BS} would rescue these changes. {D}esign {S}ixty-one severely obese subjects, candidates for adjustable gastric banding ({AG} {B}, n=20) or {R}oux-en-{Y}gastric bypass ({RYGB}, n=41), were enrolled. {T}wenty-four subjects were followed at 1, 3 and 12 months post-{BS}. {G}ut microbiota and serum metabolome were analysed using shotgun metagenomics and liquid chromatography mass spectrometry ({LC}-{MS}). {C}onfirmation groups were included. {R}esults {L} ow gene richness ({LGC}) was present in 75% of patients and correlated with increased trunk-fat mass and comorbidities (type 2 diabetes, hypertension and severity). {S}eventy-eight metagenomic species were altered with {LGC}, among which 50% were associated with adverse body composition and metabolic phenotypes. {N}ine serum metabolites (including glutarate, 3-methoxyphenylacetic acid and {L}-histidine) and functional modules containing protein families involved in their metabolism were strongly associated with low {MGR}. {BS} increased {MGR} 1 year postsurgery, but most {RYGB} patients remained with low {MGR} 1 year post{BS}, despite greater metabolic improvement than {AG} {B} patients. {C}onclusions {W}e identified major gut microbiota alterations in severe obesity, which include decreased {MGR} and related functional pathways linked with metabolic deteriorations. {T}he lack of full rescue post{BS} calls for additional strategies to improve the gut microbiota ecosystem and microbiome-host interactions in severe obesity.},
  keywords = {{FRANCE}},
  booktitle = {},
  journal = {{G}ut},
  volume = {68},
  numero = {1},
  pages = {70--82},
  ISSN = {0017-5749},
  year = {2019},
  DOI = {10.1136/gutjnl-2018-316103},
  URL = {https://www.documentation.ird.fr/hor/fdi:010074930},
}