@article{fdi:010074913,
  title = {{M}etal subcellular partitioning determines excretion pathways and sensitivity to cadmium toxicity in two marine fish species},
  author = {{L}e {C}roizier, {G}. and {L}acroix, {C}. and {A}rtigaud, {S}. and {L}e {F}loch, {S}. and {M}unaron, {J}ean-{M}arie and {R}affray, {J}ean and {P}enicaud, {V}. and {R}ouget, {M}. {L}. and {L}a{\¨e}, {R}aymond and {T}ito de {M}orais, {L}uis},
  editor = {},
  language = {{ENG}},
  abstract = {{S}ubcellular cadmium ({C}d) partitioning was investigated in the liver of two marine fish species, the {E}uropean sea bass {D}icentrarchus labrax and the {S}enegalese sole {S}olea senegalensis, dietary exposed to an environmentally realistic {C}d dose for two months followed by a two-month depuration. {T}he two species displayed different handling strategies during the depuration period. {C}d was largely bound to detoxifying fractions such as heat stable proteins ({HSP}) including metallothioneins ({MT}) in sea bass, while {C}d was more linked to sensitive fractions such as organelles in sole. {W}hole liver concentrations and subcellular partitioning were also determined for essential elements. {T}he greatest impairment of essential metal homeostasis due to {C}d exposure was found in sole. {T}hese elements followed the {C}d partitioning pattern, suggesting that they are involved in antioxidant responses against {C}d toxicity. {C}d consumption diminished sole growth in terms of body weight, probably due to lipid storage impairment. {T}he contrasting partitioning patterns showed by the two species might imply different pathways for {C}d elimination from the liver. {I}n sea bass, {MT}-bound {C}d would be excreted through bile or released into blood, crossing the cell membrane via a protein transporter. {I}n sole, {MRG}-bound {C}d would be sequestered by organelles before being released into the blood via vesicular exocytosis. {T}hese distinct strategies in cellular {C}d handling in the liver might account for differential sensitivity to {C}d toxicity and differential {C}d excretion pathways between the two marine fish species.},
  keywords = {{S}ub-cellular fractionation ; {D}icentrarchus labrax ; {S}olea senegalensis ; {E}ssential element distribution ; {E}limination ; {D}epuration},
  booktitle = {},
  journal = {{C}hemosphere},
  volume = {217},
  numero = {},
  pages = {754--762},
  ISSN = {0045-6535},
  year = {2019},
  DOI = {10.1016/j.chemosphere.2018.10.212},
  URL = {https://www.documentation.ird.fr/hor/fdi:010074913},
}