@article{fdi:010074888,
  title = {{C}hromatin changes in {A}nopheles gambiae induced by {P}lasmodium falciparum infection},
  author = {{R}uiz, {J}. {L}. and {Y}erbanga, {R}. {S}. and {L}ef{\`e}vre, {T}hierry and {O}uedraogo, {J}. {B}. and {C}orces, {V}. {G}. and {G}omez-{D}iaz, {E}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground{I}nfection by the human malaria parasite leads to important changes in mosquito phenotypic traits related to vector competence. {H}owever, we still lack a clear understanding of the underlying mechanisms and, in particular, of the epigenetic basis for these changes. {W}e have examined genome-wide distribution maps of {H}3{K}27ac, {H}3{K}9ac, {H}3{K}9me3 and {H}3{K}4me3 by {C}h{IP}-seq and the transcriptome by {RNA}-seq, of midguts from {A}nopheles gambiae mosquitoes blood-fed uninfected and infected with natural isolates of the human malaria parasite {P}lasmodium falciparum in {B}urkina {F}aso.{R}esults{W}e report 15,916 regions containing differential histone modification enrichment between infected and uninfected, of which 8339 locate at promoters and/or intersect with genes. {T}he functional annotation of these regions allowed us to identify infection-responsive genes showing differential enrichment in various histone modifications, such as {CLIP} proteases, antimicrobial peptides-encoding genes, and genes related to melanization responses and the complement system. {F}urther, the motif analysis of regions differentially enriched in various histone modifications predicts binding sites that might be involved in the cis-regulation of these regions, such as {D}eaf1, {P}angolin and {D}orsal transcription factors ({TF}s). {S}ome of these {TF}s are known to regulate immunity gene expression in {D}rosophila and are involved in the {N}otch and {JAK}/{STAT} signaling pathways.{C}onclusions{T}he analysis of malaria infection-induced chromatin changes in mosquitoes is important not only to identify regulatory elements and genes underlying mosquito responses to {P}. falciparum infection, but also for possible applications to the genetic manipulation of mosquitoes and to other mosquito-borne systems.},
  keywords = {{H}uman malaria ; {M}osquitoes ; {H}istone modifications ; {G}ene regulation ; {C}h{IP}-seq ; {RNA}-seq ; {T}ranscriptome ; {E}pigenome ; {AFRIQUE} {SUBSAHARIENNE} ; {BURKINA} {FASO}},
  booktitle = {},
  journal = {{E}pigenetics and {C}hromatin},
  volume = {12},
  numero = {1},
  pages = {art. 5 [18 p.]},
  ISSN = {1756-8935},
  year = {2019},
  DOI = {10.1186/s13072-018-0250-9},
  URL = {https://www.documentation.ird.fr/hor/fdi:010074888},
}