@article{fdi:010074884,
  title = {{G}rowth status, inflammation, and enteropathy in young children in northern {T}anzania},
  author = {{W}irth, {J}. {P}. and {K}itilya, {B}. and {P}etry, {N}. and {P}ray{G}od, {G}. and {V}eryser, {S}. and {M}ngara, {J}. and {Z}wahlen, {C}. and {W}ieringa, {F}ranck and {B}erger, {J}acques and de {O}nis, {M}. and {R}ohner, {F}. and {B}ecquey, {E}.},
  editor = {},
  language = {{ENG}},
  abstract = {{R}ecent evidence suggests that enteropathy of the gut due to environmental conditions (i.e., environmental enteropathy [{EE}]) in young children is negatively associated with linear growth. {U}sing a case-control study design, we examined the potential determinants of stunting in stunted and non-stunted children 22-28 months of age. {P}otential determinants included inflammation biomarkers {C}-reactive protein, alpha-1-acid glycoprotein ({AGP}), and endotoxin-core antibody ({E}ndo{CA}b) measured in serum samples; enteropathy markers alpha-1-antitrypsin, neopterin, myeloperoxidase ({MPO}) measured in stools samples; and demographic, health, feeding, and household characteristics. {W}e also explored the determinants of {EE} by testing associations of composite {EE} scores and individual biomarkers with potential risk factors. {F}ifty-two percent of children (n = 310) were found to be stunted, and mean height-for-age {Z} scores ({HAZ}) were -1.22 (standard deviation [{SD}] +/- 0.56) among non-stunted (control) children and -2.82 ({SD} +/- 0.61) among stunted (case) children. {C}hild {HAZ} was significantly ({P} < 0.05) and inversely associated with {AGP}, and child stunting was significantly positively associated ({P} < 0.05) with low dietary diversity, severe household hunger, and absence of soap in the household. {A}lpha-1-acid glycoprotein and {E}ndo{CA}b concentrations were also significantly higher ({P} < 0.05) among children in households with no soap. {O}ur study documented a seemingly localized cultural practice of young children (25%) being fed their dirty bathwater, which was associated with significantly higher concentrations of {MPO} ({P} < 0.05). {A}lpha-1-acid glycoprotein showed the most consistent associations with child growth and hygiene practices, but fecal {EE} biomarkers were not associated with child growth. {T}he lack of retrospective data in our study may explain the null findings related to fecal {EE} biomarkers and child growth.},
  keywords = {{TANZANIE}},
  booktitle = {},
  journal = {{A}merican {J}ournal of {T}ropical {M}edicine and {H}ygiene},
  volume = {100},
  numero = {1},
  pages = {192--201},
  ISSN = {0002-9637},
  year = {2019},
  DOI = {10.4269/ajtmh.17-0720},
  URL = {https://www.documentation.ird.fr/hor/fdi:010074884},
}