@article{fdi:010074860,
  title = {{A} saliva-based rapid test to quantify the infectious subclinical malaria parasite reservoir},
  author = {{T}ao, {D}. {Y}. and {M}c{G}ill, {B}. and {H}amerly, {T}. and {K}obayashi, {T}. and {K}hare, {P}. and {D}ziedzic, {A}. and {L}eski, {T}. and {H}oltz, {A}. and {S}hull, {B}. and {J}edlicka, {A}. {E}. and {W}alzer, {A}. and {S}lowey, {P}. {D}. and {S}lowey, {C}. {C}. and {N}sango, {S}. {E}. and {S}tenger, {D}. {A}. and {C}haponda, {M}. and {M}ulenga, {M}. and {J}acobsen, {K}. {H}. and {S}ullivan, {D}. {J}. and {R}yan, {S}. {J}. and {A}nsumana, {R}. and {M}oss, {W}. {J}. and {M}orlais, {I}sabelle and {D}inglasan, {R}. {R}.},
  editor = {},
  language = {{ENG}},
  abstract = {{A} large proportion of ongoing malaria parasite transmission is attributed to low-density subclinical infections not readily detected by available rapid diagnostic tests ({RDT}s) or microscopy. {P}lasmodium fakiparum gametocyte carriage is subclinical, but gametocytemic individuals comprise the parasite reservoir that leads to infection of mosquitoes and local transmission. {E}ffective detection and quantification of these carriers can help advance malaria elimination strategies. {H}owever, no point-of-need ({PON}) {RDT}s for gametocyte detection exist, much less one that can perform noninvasive sampling of saliva outside a clinical setting. {H}ere, we report on the discovery of 35 parasite markers from which we selected a single candidate for use in a {PON} {RDT}. {W}e performed a cross-sectional, multi-omics study of saliva from 364 children with subclinical infection in {C}ameroon and {Z}ambia and produced a prototype saliva-based {PON} lateral flow immunoassay test for {P}. fakiparum gametocyte carriers. {T}he test is capable of identifying submicroscopic carriage in both clinical and nonclinical settings and is compatible with archived saliva samples.},
  keywords = {{AFRIQUE} {SUBSAHARIENNE}},
  booktitle = {},
  journal = {{S}cience {T}ranslational {M}edicine},
  volume = {11},
  numero = {473},
  pages = {art. eaan4479 [13 ]},
  ISSN = {1946-6234},
  year = {2019},
  DOI = {10.1126/scitranslmed.aan4479},
  URL = {https://www.documentation.ird.fr/hor/fdi:010074860},
}