@article{fdi:010074608,
  title = {{M}alaria and obesity : obese mice are resistant to cerebral malaria},
  author = {{R}obert, {V}incent and {B}ourgouin, {C}. and {D}epoix, {D}. and {T}houvenot, {C}. and {L}ombard, {M}. {N}. and {G}rellier, {P}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground : {T}he relationship between malaria and obesity are largely unknown. {T}his is partly due to the fact that malaria occurs mainly in tropical areas where, until recently, obesity was not prevalent. {I}t now appears, however, that obesity is emerging as a problem in developing countries. {T}o investigate the possible role of obesity on the host-parasite response to malarial infection, this study applied a murine model, which uses the existence of genetically well characterized obese mice. {M}ethods : {T}he receptivity of obese homozygous ob/ob mice was compared to the receptivity of control heterozygous ob/+ lean mice after a single injection of {P}lasmodium berghei {ANKA} sporozoites. {B}oth parasitaemia and mortality in response to infection were recorded. {R}esults : {T}he control mice developed the expected rapid neurological syndromes associated with the {ANKA} strain, leading to death after six days, in absence of high parasitaemia. {T}he obese mice, on the other hand, did not develop cerebral malaria and responded with increasing parasitaemia, which produced severe anemia leading to death 18-25 days after injection. {C}onclusion : {T}he observed major differences in outward symptoms for malarial infection in obese versus control mice indicate a link between obesity and resistance to the infection which could be addressed by malariologists studying human malaria.},
  keywords = {},
  booktitle = {},
  journal = {{M}alaria {J}ournal},
  volume = {7},
  numero = {},
  pages = {81 (6 )},
  ISSN = {1475-2875},
  year = {2008},
  DOI = {10.1186/1475-2875-7-81},
  URL = {https://www.documentation.ird.fr/hor/fdi:010074608},
}