@article{fdi:010074607,
  title = {{I}ntermittent preventive treatment for the prevention of malaria during pregnancy in high transmission areas},
  author = {{B}riand, {V}al{\'e}rie and {C}ottrell, {G}illes and {M}assougbodji, {A}chille and {C}ot, {M}ichel},
  editor = {},
  language = {{ENG}},
  abstract = {{M}alaria in pregnancy is one of the major causes of maternal morbidity and adverse birth outcomes. {I}n high transmission areas, its prevention has recently changed, moving from a weekly or bimonthly chemoprophylaxis to intermittent preventive treatment ({IPT}p). {IPT}p consists in the administration of a single curative dose of an efficacious anti-malarial drug at least twice during pregnancy - regardless of whether the woman is infected or not. {T}he drug is administered under supervision during antenatal care visits. {S}ulphadoxine-pyrimethamine ({SP}) is the drug currently recommended by the {WHO}. {W}hile {SP}-{IPT}p seems an adequate strategy, there are many issues still to be explored to optimize it. {T}his paper reviewed data on {IPT}p efficacy and discussed how to improve it. {I}n particular, the determination of both the optimal number of doses and time of administration of the drug is essential, and this has not yet been done. {A}s both foetal growth and deleterious effects of malaria are maximum in late pregnancy women should particularly be protected during this period. {M}onitoring of {IPT}p efficacy should be applied to all women, and not only to primi- and secondigravidae, as it has not been definitively established that multigravidae are not at risk for malaria morbidity and mortality. {I}n {HIV}-positive women, there is an urgent need for specific information on drug administration patterns (need for higher doses, possible interference with sulpha-based prophylaxis of opportunistic infections). {B}ecause of the growing level of resistance of parasites to {SP}, alternative drugs for {IPT}p are urgently needed. {M}efloquine is presently one of the most attractive options because of its long half life, high efficacy in sub-{S}aharan {A}frica and safety during pregnancy. {A}lso, efforts should be made to increase {IPT}p coverage by improving the practices of health care workers, the motivation of women and their perception of malaria complications in pregnancy. {B}ecause {IPT}p is not applicable in early pregnancy, which is a period when malaria may also be deleterious for women and their offspring, there is a necessity to integrate this strategy with other preventive measures which can be applied earlier in pregnancy such as insecticide-treated nets.},
  keywords = {{BENIN} ; {AFRIQUE} {DE} {L}'{OUEST}},
  booktitle = {},
  journal = {{M}alaria {J}ournal},
  volume = {6},
  numero = {},
  pages = {[7  en ligne]},
  ISSN = {1475-2875},
  year = {2007},
  DOI = {10.1186/1475-2875-6-160},
  URL = {https://www.documentation.ird.fr/hor/fdi:010074607},
}