Sherrard-Smith E. auteur aut IRD Griffin J. T. auteur aut IRD Winskill P. auteur aut IRD Corbel Vincent auteur aut IRD Pennetier Cédric auteur aut IRD Djenontin A. auteur aut IRD Moore S. auteur aut IRD Richardson J. H. auteur aut IRD Muller P. auteur aut IRD Edi C. auteur aut IRD Protopopoff N. auteur aut IRD Oxborough R. auteur aut IRD Agossa F. auteur aut IRD N'Guessan R. auteur aut IRD Rowland M. auteur aut IRD Churcher T. S. auteur aut IRD text journalArticle eng text/pdf reformatted digital access Indoor residual spraying (IRS) is an important part of malaria control. There is a growing list of insecticide classes; pyrethroids remain the principal insecticide used in bednets but recently, novel non-pyrethroid IRS products, with contrasting impacts, have been introduced. There is an urgent need to better assess product efficacy to help decision makers choose effective and relevant tools for mosquito control. Here we use experimental hut trial data to characterise the entomological efficacy of widely-used, novel IRS insecticides. We quantify their impact against pyrethroid-resistant mosquitoes and use a Plasmodium falciparum transmission model to predict the public health impact of different IRS insecticides. We report that long-lasting IRS formulations substantially reduce malaria, though their benefit over cheaper, shorter-lived formulations depends on local factors including bednet use, seasonality, endemicity and pyrethroid resistance status of local mosquito populations. We provide a framework to help decision makers evaluate IRS product effectiveness. specialized BENIN COTE D'IVOIRE BURKINA FASO TANZANIE 052 020 9 art. 4982 [13 p.] 2018 2041-1723 https://www.documentation.ird.fr/hor/fdi:010074501 10.1038/s41467-018-07357-w 2041-1723 [F B010074501] https://www.documentation.ird.fr/hor/fdi:010074501 https://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers18-12/010074501.pdf IRD - Base Horizon / Pleins textes 2019-01-10 2023-07-11 fdi:010074501 fre