Klitting R. auteur aut IRD Fischer C. auteur aut IRD Drexler J. F. auteur aut IRD Gould E. A. auteur aut IRD Roiz David auteur aut IRD Paupy Christophe auteur aut IRD de Lamballerie X. auteur aut IRD text journalArticle eng text/pdf reformatted digital access As revealed by the recent resurgence of yellow fever virus (YFV) activity in the tropical regions of Africa and South America, YFV control measures need urgent rethinking. Over the last decade, most reported outbreaks occurred in, or eventually reached, areas with low vaccination coverage but that are suitable for virus transmission, with an unprecedented risk of expansion to densely populated territories in Africa, South America and Asia. As reflected in the World Health Organization's initiative launched in 2017, it is high time to strengthen epidemiological surveillance to monitor accurately viral dissemination, and redefine vaccination recommendation areas. Vector-control and immunisation measures need to be adapted and vaccine manufacturing must be reconciled with an increasing demand. We will have to face more yellow fever (YF) cases in the upcoming years. Hence, improving disease management through the development of efficient treatments will prove most beneficial. Undoubtedly, these developments will require in-depth descriptions of YFV biology at molecular, physiological and ecological levels. This second section of a two-part review describes the current state of knowledge and gaps regarding the molecular biology of YFV, along with an overview of the tools that can be used to manage the disease at the individual, local and global levels. specialized yellow fever virus flavivirus vector-borne transmission emergence AFRIQUE CARAIBE AMERIQUE ASIE EUROPE MOYEN ORIENT 052 050 9 9 art. 425 [37 p.] 2018 2073-4425 https://www.documentation.ird.fr/hor/fdi:010074358 10.3390/genes9090425 2073-4425 [F B010074358] https://www.documentation.ird.fr/hor/fdi:010074358 https://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers18-11/010074358.pdf IRD - Base Horizon / Pleins textes 2018-12-06 2023-07-11 fdi:010074358 fre