@article{fdi:010074358, title = {{W}hat does the future hold for yellow fever virus ? ({II})}, author = {{K}litting, {R}. and {F}ischer, {C}. and {D}rexler, {J}. {F}. and {G}ould, {E}. {A}. and {R}oiz, {D}avid and {P}aupy, {C}hristophe and de {L}amballerie, {X}.}, editor = {}, language = {{ENG}}, abstract = {{A}s revealed by the recent resurgence of yellow fever virus ({YFV}) activity in the tropical regions of {A}frica and {S}outh {A}merica, {YFV} control measures need urgent rethinking. {O}ver the last decade, most reported outbreaks occurred in, or eventually reached, areas with low vaccination coverage but that are suitable for virus transmission, with an unprecedented risk of expansion to densely populated territories in {A}frica, {S}outh {A}merica and {A}sia. {A}s reflected in the {W}orld {H}ealth {O}rganization's initiative launched in 2017, it is high time to strengthen epidemiological surveillance to monitor accurately viral dissemination, and redefine vaccination recommendation areas. {V}ector-control and immunisation measures need to be adapted and vaccine manufacturing must be reconciled with an increasing demand. {W}e will have to face more yellow fever ({YF}) cases in the upcoming years. {H}ence, improving disease management through the development of efficient treatments will prove most beneficial. {U}ndoubtedly, these developments will require in-depth descriptions of {YFV} biology at molecular, physiological and ecological levels. {T}his second section of a two-part review describes the current state of knowledge and gaps regarding the molecular biology of {YFV}, along with an overview of the tools that can be used to manage the disease at the individual, local and global levels.}, keywords = {yellow fever virus ; flavivirus ; vector-borne transmission ; emergence ; {AFRIQUE} ; {CARAIBE} ; {AMERIQUE} ; {ASIE} ; {EUROPE} ; {MOYEN} {ORIENT}}, booktitle = {}, journal = {{G}enes}, volume = {9}, numero = {9}, pages = {art. 425 [37 p.]}, ISSN = {2073-4425}, year = {2018}, DOI = {10.3390/genes9090425}, URL = {https://www.documentation.ird.fr/hor/fdi:010074358}, }