@article{fdi:010074161,
  title = {{I}nsights into the processes that drive the evolution of drug resistance in {M}ycobacterium tuberculosis},
  author = {{N}guyen, {Q}. {H}. and {C}ontamin, {L}ucie and {N}guyen, {T}. {V}. {A}. and {B}anuls, {A}nne-{L}aure},
  editor = {},
  language = {{ENG}},
  abstract = {{A}t present, the successful transmission of drug-resistant {M}ycobacterium tuberculosis, including multidrug-resistant ({MDR}) and extensively drug-resistant ({XDR}) strains, in human populations, threatens tuberculosis control worldwide. {D}ifferently from many other bacteria, {M}. tuberculosis drug resistance is acquired mainly through mutations in specific drug resistance-associated genes. {T}he panel of mutations is highly diverse, but depends on the affected gene and {M}. tuberculosis genetic background. {T}he variety of genetic profiles observed in drug-resistant clinical isolates underlines different evolutionary trajectories towards multiple drug resistance, although some mutation patterns are prominent. {T}his review discusses the intrinsic processes that may influence drug resistance evolution in {M}. tuberculosis, such as mutation rate, drug resistance-associated mutations, fitness cost, compensatory mutations and epistasis. {T}his knowledge should help to better predict the risk of emergence of highly resistant {M}. tuberculosis strains and to develop new tools and strategies to limit the development and spread of {MDR} and {XDR} strains.},
  keywords = {compensatory mutation ; drug resistance mutation ; epistasis ; evolution ; fitness cost ; multidrug-resistant tuberculosis ; mycobacterium tuberculosis},
  booktitle = {},
  journal = {{E}volutionary {A}pplications},
  volume = {11},
  numero = {9},
  pages = {1498--1511},
  ISSN = {1752-4571},
  year = {2018},
  DOI = {10.1111/eva.12654},
  URL = {https://www.documentation.ird.fr/hor/fdi:010074161},
}