Guy M. auteur aut IRD Accrombessi M. auteur aut IRD Fievet Nadine auteur aut IRD Yovo E. auteur aut IRD Massougbodji A. auteur aut IRD Le Bot B. auteur aut IRD Glorennec P. auteur aut IRD Bodeau-Livinec F. auteur aut IRD Briand Valérie auteur aut IRD text journalArticle eng text/pdf born digital access During pregnancy, fetal development can be hindered by maternal exposure to toxic elements and abnormal concentrations of trace elements. Few data are available in African countries. Our goal was to assess the body burden of lead (Pb), cadmium (Cd), manganese (Mn), zinc (Zn) and copper (Cu) in pregnant women in Benin. The study was carried out in So-Ava district, from November 2015 to April 2016. Sixty women were recruited from the RECIPAL pre-conceptional cohort study. In all women, blood samples were collected during the first trimester of pregnancy. Thirty-two women had additional maternal and cord blood samples collected at delivery. Blood samples were analyzed by inductively coupled plasma mass spectrometry. At delivery, Cd median (IQR) concentration in maternal blood was 0.34 mu g/L (0.24-0.46) in this non-smoking population. Pb median (IQR) concentration in maternal blood at delivery was 37.4 mu g/L (30.5-52.0), with 31.3% of blood Pb levels above the 50 mu pg/L threshold. These pregnant women lived in semi-rural lakeside villages. Potential sources of Pb exposure identified during pregnancy were having water supply by drill pump and activities such as smoking fish by the woman and fishing by the household head. At delivery, Zn, Cu, and Mn median (IQR) concentrations in maternal blood were, respectively, 5415 mu g/L (4894-5822), 1609 mu g/L (1295-1771) and 16.0 mu g/L (12.5-20.8). Pb, Cd, Mn and Cu blood concentrations were significantly higher at delivery than during the first trimester of pregnancy. Pb, Cd, Zn and Cu concentrations were significantly lower in cord blood than in maternal blood, contrary to Mn concentration, which was significantly higher in cord blood than in maternal blood at delivery. This exploratory study is the first one performed in Benin, and warns us about exposition of women from S (o) over cap -Ava district to Pb and Cd during pregnancy. specialized Environmental pollutants Trace elements Pregnancy Benin Public health BENIN 050 020 038 167 198-206 2018 0013-9351 https://www.documentation.ird.fr/hor/fdi:010074158 10.1016/j.envres.2018.06.054 0013-9351 [F B010074158] https://www.documentation.ird.fr/hor/fdi:010074158 https://www.documentation.ird.fr/intranet/publi/2018/11/010074158.pdf Accès réservé (Intranet de l'IRD) IRD - Base Horizon / Pleins textes 2018-12-06 2023-07-11 fdi:010074158 fre