@article{fdi:010074096,
  title = {{T}hiamine deficiency disorders : diagnosis, prevalence, and a roadmap for global control programs},
  author = {{W}hitfield, {K}. {C}. and {B}ourassa, {M}. {W}. and {A}damolekun, {B}. and {B}ergeron, {G}. and {B}ettendorff, {L}. and {B}rown, {K}. {H}. and {C}ox, {L}. and {F}attal-{V}alevski, {A}. and {F}ischer, {P}. {R}. and {F}rank, {E}. {L}. and {H}iffler, {L}. and {H}laing, {L}. {M}. and {J}efferds, {M}. {E}. and {K}apner, {H}. and {K}ounnavong, {S}. and {M}ousavi, {M}. {P}. {S}. and {R}oth, {D}. {E}. and {T}saloglou, {M}. {N}. and {W}ieringa, {F}ranck and {C}ombs, {G}. {F}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}hiamine is an essential micronutrient that plays a key role in energy metabolism. {M}any populations worldwide may be at risk of clinical or subclinical thiamine deficiencies, due to famine, reliance on staple crops with low thiamine content, or food preparation practices, such as milling grains and washing milled rice. {C}linical manifestations of thiamine deficiency are variable; this, along with the lack of a readily accessible and widely agreed upon biomarker of thiamine status, complicates efforts to diagnose thiamine deficiency and assess its global prevalence. {S}trategies to identify regions at risk of thiamine deficiency through proxy measures, such as analysis of food balance sheet data and month-specific infant mortality rates, may be valuable for understanding the scope of thiamine deficiency. {U}rgent public health responses are warranted in high-risk regions, considering the contribution of thiamine deficiency to infant mortality and research suggesting that even subclinical thiamine deficiency in childhood may have lifelong neurodevelopmental consequences. {F}ood fortification and maternal and/or infant thiamine supplementation have proven effective in raising thiamine status and reducing the incidence of infantile beriberi in regions where thiamine deficiency is prevalent, but trial data are limited. {E}fforts to determine culturally and environmentally appropriate food vehicles for thiamine fortification are ongoing.},
  keywords = {thiamine deficiency ; beriberi ; {LMIC} ; nutrition ; erythrocyte ; transketolase ; thiamine diphosphate},
  booktitle = {},
  journal = {{A}nnals of the {N}ew {Y}ork {A}cademy of {S}ciences},
  volume = {1430},
  numero = {1},
  pages = {3--43},
  ISSN = {0077-8923},
  year = {2018},
  DOI = {10.1111/nyas.13919},
  URL = {https://www.documentation.ird.fr/hor/fdi:010074096},
}