@article{fdi:010074002,
  title = {{A}nopheles salivary biomarker as a proxy for estimating {P}lasmodium falciparum malaria exposure on the {T}hailand-{M}yanmar border},
  author = {{Y}a-{U}mphan, {P}. and {C}erqueira, {D}. and {C}ottrell, {G}illes and {P}arker, {D}. {M}. and {F}owkes, {F}. {J}. {I}. and {N}osten, {F}. and {C}orbel, {V}incent},
  editor = {},
  language = {{ENG}},
  abstract = {{T}imely identification and treatment of malaria transmission "hot spots" is essential to achieve malaria elimination. {H}ere we investigate the relevance of using an {A}nopheles salivary biomarker to estimate {P}lasmodium falciparum malaria exposure risk along the {T}hailand-{M}yanmar border to guide malaria control. {B}etween {M}ay 2013 and {D}ecember 2014, > 9,000 blood samples collected in a cluster randomized control trial were screened with serological assays to measure the antibody responses to {A}nopheles salivary antigen (g{SG}6-{P}1) and {P}. falciparum malaria antigens (circumsporozoite protein, merozoite surface protein 119 [{MSP}-1(19)]). {P}lasmodium falciparum infections were monitored through passive and active case detection. {S}eroprevalence to g{SG}6-{P}1, {MSP}-1(19), and {CSP} were 71.8% (95% {C}onfidence interval [{CI}]: 70.9, 72.7), 68.6% (95% {CI}: 67.7, 69.5), and 8.6% (95% {CI}: 8.0, 9.2), respectively. {M}ultivariate analysis showed that individuals with the highest {A}b response to g{SG}6-{P}1 had six times the odds of being positive to {CSP} antigens ({P}< 0.001) and two times the odds of {P}. falciparum infection compared with low g{SG}6-{P}1 responders ({P}= 0.004). {S}patial scan statistics revealed the presence of clusters of g{SG}6-{P}1 that partially overlapped {P}. falciparum infections. {T}he g{SG}6-{P}1 salivary biomarker represents a good proxy for estimating {P}. falciparum malaria risk and could serve to implement hot spot-targeted vector control interventions to achieve malaria elimination.},
  keywords = {{THAILANDE} ; {MYANMAR}},
  booktitle = {},
  journal = {{A}merican {J}ournal of {T}ropical {M}edicine and {H}ygiene},
  volume = {99},
  numero = {2},
  pages = {350--356},
  ISSN = {0002-9637},
  year = {2018},
  DOI = {10.4269/ajtmh.18-0081},
  URL = {https://www.documentation.ird.fr/hor/fdi:010074002},
}