@article{fdi:010073707,
  title = {{L}iver clear cell foci and viral infection are associated with non-cirrhotic, non-fibrolamellar hepatocellular carcinoma in young patients from {S}outh {A}merica},
  author = {{C}ano, {L}. and {C}erapio, {J}. {P}. and {R}uiz, {E}. and {M}archio, {A}. and {T}urlin, {B}. and {C}asavilca, {S}. and {T}axa, {L}. and {M}arti, {G}. and {D}eharo, {E}ric and {P}ineau, {P}. and {B}ertani, {S}t{\'e}phane},
  editor = {},
  language = {{ENG}},
  abstract = {{W}e previously described a divergent clinical and molecular presentation of hepatocellular carcinoma ({HCC}) in {P}eru. {T}he present study aimed to further characterize the tissue features associated with this singular nosological form of {HCC} in order to gain insight into the natural history of the disease. {W}e performed an exploratory analysis of the histology of both tumor and non-tumor liver ({NTL}) tissues from 50 {P}eruvian {HCC} patients, and compared with that of 75 individuals with non-{HCC} liver tumor or benign liver lesions as a baseline for {NTL} features. {W}e complemented this approach with a transcriptome analysis in a subset of {NTL} tissue samples and also performed an ultra-sensitive hepatitis {B} virus ({HBV}) detection in liver tissues of the patients. {O}verall, results highlighted the low rate of liver parenchymal alterations in a young patient cohort (median age: 40 years old), despite a strong prevalence of underlying {HBV} infection (c. 67%). {W}ithal, liver clear cell foci of cellular alteration were genuinely associated with {HCC} and appended to some changes in immune and {G} protein-coupled receptor gene expression ontologies. {O}ur findings confirm the occurrence of a particular setting of {HCC} in {S}outh {A}merica, a region where the pathophysiology of liver cancer remains largely unexplored.},
  keywords = {{PEROU}},
  booktitle = {},
  journal = {{S}cientific {R}eports - {N}ature},
  volume = {8},
  numero = {},
  pages = {art. 9945 [12 p.]},
  ISSN = {2045-2322},
  year = {2018},
  DOI = {10.1038/s41598-018-28286-0},
  URL = {https://www.documentation.ird.fr/hor/fdi:010073707},
}