@article{fdi:010073649,
  title = {{E}ffect of {DEET}-multiple exposures on behavior and life history traits in the malaria mosquito {A}nopheles gambiae (s.s.)},
  author = {{M}ulatier, {M}argaux and {A}lou, {L}. {P}. {A}. and {C}handre, {F}abrice and {P}ennetier, {C}{\'e}dric and {D}ormont, {L}. and {C}ohuet, {A}nna},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {V}ector-borne diseases are major public health concerns, and their control is threatened by the spread of insecticide resistance in vector populations. {I}n this context, the use of repellents is an alternative approach to limit vector-host interactions. {H}owever, prior exposure to repellents is suspected to affect mosquito behavior at the subsequent exposure, possibly reducing the efficacy of the compound. {D}espite this, the effect of mosquito experience on repellent efficacy remains poorly documented. {I}n the present study, we tested whether a first blood meal successfully obtained upon a {DEET}-treated net would affect the success at taking a second blood meal in spite of {DEET} in the malaria mosquito {A}nopheles gambiae (s. s.). {T}he impact of {DEET} on mosquito life history traits after the first and the second exposure was also measured, in order to assess the long-term consequences of multiple exposures to {DEET} in vector insects. {R}esults: {A} first blood meal obtained upon a {DEET}-treated net did not influence the success of {A}n. gambiae females to take a second blood meal in spite of {DEET}. {H}owever, data showed that a prior exposure to {DEET} negatively affected all life history traits tested in this study related to fecundity and fertility. {DEET} pre-exposed females displayed a reduction in blood engorgement at the second exposure, as well as a reduction in the number of eggs laid and in the proportion of offspring that reach adult stage. {A}lso, an increase of mosquito activity was observed during the second blood meal in {DEET}-pre-exposed females. {T}aken together, these data suggest an overall impact of {DEET} exposure on mosquito fitness. {C}onclusions: {O}ur results did not evidence any effect of a prior exposure to {DEET} on its efficacy during the second exposure. {H}owever, data show a negative impact of {DEET} exposure on mosquito fitness. {T}hese results give insights to understand the long-term efficacy of the most used mosquito repellent, and highlight that {DEET} induces deleterious effects on mosquito fitness in addition to repellency, potentially increasing its efficacy for controlling vector-borne diseases.},
  keywords = {{DEET} ; {M}ultiple-exposures ; {A}n. gambiae ; {E}xperience ; {F}itness},
  booktitle = {},
  journal = {{P}arasites and {V}ectors},
  volume = {11},
  numero = {},
  pages = {art. 432 [10 p.]},
  ISSN = {1756-3305},
  year = {2018},
  DOI = {10.1186/s13071-018-3024-0},
  URL = {https://www.documentation.ird.fr/hor/fdi:010073649},
}