Fiorilli V. auteur aut IRD Vannini C. auteur aut IRD Ortolani F. auteur aut IRD Garcia-Seco D. auteur aut IRD Chiapello M. auteur aut IRD Novero M. auteur aut IRD Domingo G. auteur aut IRD Terzi V. auteur aut IRD Morcia C. auteur aut IRD Bagnaresi P. auteur aut IRD Moulin Lionel auteur aut IRD Bracale M. auteur aut IRD Bonfante P. auteur aut IRD text journalArticle eng text/pdf reformatted digital access Besides improved mineral nutrition, plants colonised by arbuscular mycorrhizal (AM) fungi often display increased biomass and higher tolerance to biotic and abiotic stresses. Notwithstanding the global importance of wheat as an agricultural crop, its response to AM symbiosis has been poorly investigated. We focused on the role of an AM fungus on mineral nutrition of wheat, and on its potential protective effect against Xanthomonas translucens. To address these issues, phenotypical, molecular and metabolomic approaches were combined. Morphological observations highlighted that AM wheat plants displayed an increased biomass and grain yield, as well as a reduction in lesion area following pathogen infection. To elucidate the molecular mechanisms underlying the mycorrhizal phenotype, we investigated changes of transcripts and proteins in roots and leaves during the double (wheat-AM fungus) and tripartite (wheat-AM fungus-pathogen) interaction. Transcriptomic and proteomic profiling identified the main pathways involved in enhancing plant biomass, mineral nutrition and in promoting the bio-protective effect against the leaf pathogen. Mineral and amino acid contents in roots, leaves and seeds, and protein oxidation profiles in leaves, supported the omics data, providing new insight into the mechanisms exerted by AM symbiosis to confer stronger productivity and enhanced resistance to X. translucens in wheat. specialized 084 076 8 art. 9625 [ p.] 2018 2045-2322 https://www.documentation.ird.fr/hor/fdi:010073182 10.1038/s41598-018-27622-8 2045-2322 [F B010073182] https://www.documentation.ird.fr/hor/fdi:010073182 https://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers18-08/010073182.pdf IRD - Base Horizon / Pleins textes 2018-09-03 2018-09-04 fdi:010073182 fre