@article{fdi:010073156,
  title = {{M}odeling the impact of {P}lasmodium falciparum sexual stage immunity on the composition and dynamics of the human infectious reservoir for malaria in natural settings},
  author = {{O}uedraogo, {A}. {L}. and {E}ckhoff, {P}. {A}. and {L}uty, {A}drian and {R}oeffen, {W}. and {S}auerwein, {R}. {W}. and {B}ousema, {T}. and {W}enger, {E}. {A}.},
  editor = {},
  language = {{ENG}},
  abstract = {{M}alaria transmission remains high in {S}ub-{S}aharan {A}frica despite large-scale implementation of malaria control interventions. {A} comprehensive understanding of the transmissibility of infections to mosquitoes may guide the design of more effective transmission reducing strategies. {T}he impact of {P}. falciparum sexual stage immunity on the infectious reservoir for malaria has never been studied in natural settings. {R}epeated measurements were carried out at start-wet, peak-wet and dry season, and provided data on antibody responses against gametocyte/gamete antigens {P}fs48/45 and {P}fs230 as anti-gametocyte immunity. {D}ata on high and low-density infections and their infectiousness to anopheline mosquitoes were obtained using quantitative molecular methods and mosquito feeding assays, respectively. {A}n event-driven model for {P}. falciparum sexual stage immunity was developed and fit to data using an agent based malaria model infrastructure. {W}e found that {P}fs48/45 and {P}fs230 antibody densities increased with increasing concurrent gametocyte densities; associated with 55-70% reduction in oocyst intensity and achieved up to 44% reduction in proportions of infected mosquitoes. {W}e showed that {P}. falciparum sexual stage immunity significantly reduces transmission of microscopic (p < 0.001) but not submicroscopic (p = 0.937) gametocyte infections to mosquitoes and that incorporating sexual stage immunity into mathematical models had a considerable impact on the contribution of different age groups to the infectious reservoir of malaria. {H}uman antibody responses to gametocyte antigens are likely to be dependent on recent and concurrent high-density gametocyte exposure and have a pronounced impact on the likelihood of onward transmission of microscopic gametocyte densities compared to low density infections. {O}ur mathematical simulations indicate that anti-gametocyte immunity is an important factor for predicting and understanding the composition and dynamics of the human infectious reservoir for malaria.},
  keywords = {{AFRIQUE} {SUBSAHARIENNE}},
  booktitle = {},
  journal = {{PL}o{S} {P}athogens},
  volume = {14},
  numero = {5},
  pages = {e1007034 [23 p.]},
  ISSN = {1553-7366},
  year = {2018},
  DOI = {10.1371/journal.ppat.1007034},
  URL = {https://www.documentation.ird.fr/hor/fdi:010073156},
}