Unguiculins A-C : cytotoxic bis-guanidine alkaloids from the French Polynesian sponge, Monanchora n. sp.

Unguiculins A-C : cytotoxic bis-guanidine alkaloids from the French Polynesian sponge, Monanchora n. sp. El-Demerdash A. auteur aut IRD Moriou C. auteur aut IRD Martin M. T. auteur aut IRD Petek Sylvain auteur aut IRD Debitus Cécile auteur aut IRD Al-Mourabit A. auteur aut IRD text journalArticle eng text/pdf born digital access Two new acyclic bis-guanidine alkaloids, unguiculins B-C (2-3), were isolated from a French Polynesian sponge Monanchora n. sp. together with the known compound unguiculin A (1). Their structures were established by spectroscopic data interpretation and comparison with the literature. Unguiculins A-C displayed antiproliferative and cytotoxic efficacy against several human cancer cells with IC50 values in the micromolar range. [GRAPHICS] . specialized Monanchora Crambeidae unguiculin guanidine spermidine alkaloid PACIFIQUE POLYNESIE FRANCAISE 035 052 Natural Product Research 32 13 1512-1517 2018 1478-6419 https://www.documentation.ird.fr/hor/fdi:010073062 10.1080/14786419.2017.1385011 1478-6419 [F B010073062] https://www.documentation.ird.fr/hor/fdi:010073062 https://www.documentation.ird.fr/intranet/publi/2018/06/010073062.pdf Accès réservé (Intranet de l'IRD) IRD - Base Horizon / Pleins textes 2018-07-03 2023-07-11 fdi:010073062 fre