Horizon 1 1 17 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES Unguiculins A-C : cytotoxic bis-guanidine alkaloids from the French Polynesian sponge, Monanchora n. sp. Natural Product Research 1512-1517 Monanchora Crambeidae unguiculin guanidine spermidine alkaloid PACIFIQUE POLYNESIE FRANCAISE 2018 fdi:010073062 ENG Natural Product Research 1478-6419 ISI:000433990900004 13 10.1080/14786419.2017.1385011 https://www.documentation.ird.fr/hor/fdi:010073062 https://www.documentation.ird.fr/intranet/publi/2018/06/010073062.pdf 32 Horizon (IRD) Two new acyclic bis-guanidine alkaloids, unguiculins B-C (2-3), were isolated from a French Polynesian sponge Monanchora n. sp. together with the known compound unguiculin A (1). Their structures were established by spectroscopic data interpretation and comparison with the literature. Unguiculins A-C displayed antiproliferative and cytotoxic efficacy against several human cancer cells with IC50 values in the micromolar range. [GRAPHICS] . 035 ; 052 UR241 / UR195 Égypte