%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Paboriboune, P.
%A Vial, Thomas
%A Chassagne, F.
%A Sitbounlang, P.
%A Soundala, S.
%A Bertani, Stéphane
%A Sengmanothong, D.
%A Babin, F. X.
%A Steenkeste, N.
%A Deny, P.
%A Pineau, P.
%A Deharo, Eric
%T A seven-year retrospective study on the surveillance of hepatitis B in Laos
%D 2018
%L fdi:010072740
%G ENG
%J International Journal of Hepatology
%@ 2090-3448
%K LAOS
%M ISI:000430270700001
%P art. ID 9462475 [11 ]
%R 10.1155/2018/9462475
%U https://www.documentation.ird.fr/hor/fdi:010072740
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers18-05/010072740.pdf
%W Horizon (IRD)
%X Objective. Lao PDR is one of the most highly endemic countries for hepatitis B in Asia and the second country for liver cancer incidence. Therefore, the follow-up of infected individuals through predictive serological markers is of utmost importance to monitor the progression of the pathology and take the decision on treatment. Methods. A retrospective-descriptive cohort study was conducted on 3,857 HBV-infected patients. Information about infection status (viral load, VL), liver function (aminotransferases), and treatments was recorded. Results. M/F sex ratio was 1.77 for a median age of 37. Patients under 37 displayed higher VL than older ones and men had higher VL than women. Initial VL ranged from <50 IU/mL to 2.5 10(13) IU/mL. Median aminotransferase values were 45.5 U/L for ALAT and 44 U/L for ASAT, ranging from <8 to >2,000 U/L. Men had higher aminotransferase than women. Globally 20% of patients received treatment (mainly immunostimulant and reverse-transcriptase inhibitors); 11% had high levels of VL and liver enzymes, but only 2% of them were treated. Conclusion. Public health decisions should be taken urgently to rationalise vaccination and provide fair access to early diagnosis and treatment; otherwise the burden of HBV-associated diseases will be overwhelming for Laos in the near future.
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