Thomas F. auteur aut IRD Kareva I. auteur aut IRD Raven N. auteur aut IRD Hamede R. auteur aut IRD Pujol P. auteur aut IRD Roche Benjamin auteur aut IRD Ujvari B. auteur aut IRD text journalArticle eng text/pdf born digital access Evolved dependence is a process through which one species becomes 'dependent' on another following a long evolutionary history of interaction. This happens when adaptations selected in the first species for interacting lead to fitness costs when the second species is not encountered. Evolved dependence is frequent in host-parasite interactions, where hosts may achieve a higher fitness in the presence of the parasite than in its absence. Since oncogenic manifestations are (i) ubiquitous across multicellular life, (ii) involved in parasitic-like interactions with their hosts, and (iii) have effectively driven the selection of numerous adaptations, it is possible that multicellular organisms display evolved dependence in response to oncogenic processes. We provide a comprehensive overview of the topic, including the implications for cancer prevention and treatment. specialized 050 020 33 4 269-276 2018 0169-5347 https://www.documentation.ird.fr/hor/fdi:010072667 10.1016/j.tree.2018.01.012 0169-5347 [F B010072667] https://www.documentation.ird.fr/hor/fdi:010072667 https://www.documentation.ird.fr/intranet/publi/2018/04/010072667.pdf Accès réservé (Intranet de l'IRD) IRD - Base Horizon / Pleins textes 2018-05-04 2023-07-11 fdi:010072667 fre