@article{fdi:010072662,
  title = {{S}ubmicroscopic placental infection by non-falciparum {P}lasmodium spp.},
  author = {{D}oritchamou, {J}. {Y}. {A}. and {A}kuffo, {R}. {A}. and {M}oussiliou, {A}. and {L}uty, {A}drian and {M}assougbodji, {A}. and {D}eloron, {P}hilippe and {T}uikue {N}dam, {N}icaise},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground {A}mong the {P}lasmodium species that infect humans, adverse effects of {P}. falciparum and {P}. vivax have been extensively studied and reported with respect to poor outcomes particularly in first time mothers and in pregnant women living in areas with unstable malaria transmission. {A}lthough, other non-falciparum malaria infections during pregnancy have sometimes been reported, little is known about the dynamics of these infections during pregnancy. {M}ethods and findings {U}sing a quantitative {PCR} approach, blood samples collected from {B}eninese pregnant women during the first antenatal visit ({ANV}) and at delivery including placental blood were screened for {P}lasmodium spp. {R}isk factors associated with {P}lasmodium spp. infection during pregnancy were assessed as well as the relationships with pregnancy outcomes. {P}. falciparum was the most prevalent {P}lasmodium species detected during pregnancy, irrespective either of parity, of age or of season during which the infection occurred. {A}lthough no {P}. vivax infections were detected in this cohort, {P}. malariae (9.2%) and {P}. ovale (5.8%) infections were observed in samples collected during the first {ANV}. {T}hese non-falciparum infections were also detected in maternal peripheral blood (1.3% for {P}. malariae and 1.2% for {P}. ovale) at delivery. {I}mportantly, higher prevalence of {P}. malariae (5.5%) was observed in placental than peripheral blood while that of {P}. ovale was similar (1.8% in placental blood). {A}mong the non-falciparum infected pregnant women with paired peripheral and placental samples, {P}. malariae infections in the placental blood was significantly higher than in the peripheral blood, suggesting a possible affinity of {P}. malariae for the placenta. {H}owever, no assoctiation of non-falciparum infections and the pregnancy outcomes was observed {C}onclusions {O}verall this study provided insights into the molecular epidemiology of {P}lasmodium spp. infection during pregnancy, indicating placental infection by non-falciparum {P}lasmodium and the lack of association of these infections with adverse pregnancy outcomes.},
  keywords = {},
  booktitle = {},
  journal = {{PL}o{S} {N}eglected {T}ropical {D}iseases},
  volume = {12},
  numero = {2},
  pages = {e0006279 [17 p.]},
  ISSN = {1935-2735},
  year = {2018},
  DOI = {10.1371/journal.pntd.0006279},
  URL = {https://www.documentation.ird.fr/hor/fdi:010072662},
}