El-Demerdash A. auteur aut IRD Moriou C. auteur aut IRD Toullec J. auteur aut IRD Besson M. auteur aut IRD Soulet S. auteur aut IRD Schmitt N. auteur aut IRD Petek Sylvain auteur aut IRD Lecchini D. auteur aut IRD Debitus Cécile auteur aut IRD Al-Mourabit A. auteur aut IRD text journalArticle eng text/pdf reformatted digital access Herein, we describe the isolation and spectroscopic identification of eight new tetrabrominated tyrosine alkaloids 2–9 from the Polynesian sponge Suberea ianthelliformis, along with known major compound psammaplysene D (1), N,N-dimethyldibromotyramine, 5-hydroxy xanthenuric acid, and xanthenuric acid. Cytotoxicity and acetylcholinesterase inhibition activities were evaluated for some of the isolated metabolites. They exhibited moderate antiproliferative activity against KB cancer cell lines, but psammaplysene D (1) displayed substantial cytotoxicity as well as acetylcholinesterase inhibition with IC50 values of 0.7 μM and 1.3 μM, respectively. specialized POLYNESIE FRANCAISE PACIFIQUE 035 050 16 5 art. no 146 [16 en ligne] 2018 https://www.documentation.ird.fr/hor/fdi:010072564 10.3390/md16050146 [F B010072564] https://www.documentation.ird.fr/hor/fdi:010072564 https://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers18-05/010072564.pdf IRD - Base Horizon / Pleins textes 2018-05-31 2023-07-11 fdi:010072564 fre