@article{fdi:010072471,
  title = {{I}s placental malaria a long-term risk factor for mild malaria attack in infancy ? {R}evisiting a paradigm},
  author = {{B}ouaziz, {O}. and {C}ourtin, {D}avid and {C}ottrell, {G}illes and {M}ilet, {J}acqueline and {N}uel, {G}. and {G}arcia, {A}ndr{\'e}},
  editor = {},
  language = {{ENG}},
  abstract = {{W}e aimed to determine if children born to mothers with placental malaria are more susceptible to malaria and remain at higher risk between birth and 18 months. {F}rom a public health point of view, protecting children born to infected placenta remains a priority.{C}hildren born to mothers with placental malaria ({PM}) have been described as more susceptible to the occurrence of a first malaria infection. {H}owever, whether or not these children remain more at risk during infancy has never been explored. {W}e aimed to determine if children born to mothers with {PM} are more susceptible to malaria and remain at higher risk between birth and 18 months. {F}ive hundred fifty children were followed up weekly with control of temperature and, if > 37.5{A} degrees {C}, both a rapid diagnostic test for malaria and a thick blood smear were performed. {T}aking into account environmental risk of infection, the relationship between occurrences of malaria attacks from birth to 18 months was modeled using {C}ox models for recurrent events. {PM} is not associated with an overall susceptibility to malaria but only with the delay of occurrence of the first malaria attack. {C}hildren born from mothers with {PM} tend to have an increased risk for the first malaria attack (hazard ratio [{HR}] = 1.33; {P} = .048) but not for subsequent ones ({HR} = 0.9; {P} = .46). {C}hildren who experienced 1 malaria attack were strongly at risk to develop subsequent infections independent of placental infection and environmental exposure. {T}hese results are consistent with the existence of an individual susceptibility to malaria unrelated to {PM}. {F}rom a public health point of view, protecting children born to infected placenta remains a priority, but seems insufficient to account for other frail children for whom a biomarker of frailty needs to be found.},
  keywords = {recurrent events ; placental malaria ; malaria ; susceptibility ; infants ; {BENIN}},
  booktitle = {},
  journal = {{C}linical {I}nfectious {D}iseases},
  volume = {66},
  numero = {6},
  pages = {930--935},
  ISSN = {1058-4838},
  year = {2018},
  DOI = {10.1093/cid/cix899},
  URL = {https://www.documentation.ird.fr/hor/fdi:010072471},
}