%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Bei, A. K.
%A Niang, M.
%A Deme, A. B.
%A Daniels, R. F.
%A Sarr, F. D.
%A Sokhna, Cheikh
%A Talla, C.
%A Faye, J.
%A Diagne, N.
%A Doucoure, S.
%A Mboup, S.
%A Wirth, D. F.
%A Tall, A.
%A Ndiaye, D.
%A Hartl, D. L.
%A Volkman, S. K.
%A Toure-Balde, A.
%T Dramatic changes in malaria population genetic complexity in Dielmo and Ndiop, Senegal, revealed using genomic surveillance
%D 2018
%L fdi:010072369
%G ENG
%J Journal of Infectious Diseases
%@ 0022-1899
%K malaria ; Dielmo/Ndiop ; Senegal ; genomic surveillance ; molecular barcode
%K SENEGAL ; DIELMO ; NDIOP
%M ISI:000425389100015
%N 4
%P 622-627
%R 10.1093/infdis/jix580
%U https://www.documentation.ird.fr/hor/fdi:010072369
%> https://www.documentation.ird.fr/intranet/publi/2018/03/010072369.pdf
%V 217
%W Horizon (IRD)
%X Dramatic changes in transmission intensity can impact Plasmodium population diversity. Using samples from 2 distant time-points in the Dielmo/Ndiop longitudinal cohorts from Senegal, we applied a molecular barcode tool to detect changes in parasite genotypes and complexity of infection that corresponded to changes in transmission intensity. We observed a striking statistically significant difference in genetic diversity between the 2 parasite populations. Furthermore, we identified a genotype in Dielmo and Ndiop previously observed in Thies, potentially implicating imported malaria. This genetic surveillance study validates the molecular barcode as a tool to assess parasite population diversity changes and track parasite genotypes.
%$ 052