Bei A. K., Niang M., Deme A. B., Daniels R. F., Sarr F. D., Sokhna Cheikh, Talla C., Faye J., Diagne N., Doucoure S., Mboup S., Wirth D. F., Tall A., Ndiaye D., Hartl D. L., Volkman S. K., Toure-Balde A. (2018). Dramatic changes in malaria population genetic complexity in Dielmo and Ndiop, Senegal, revealed using genomic surveillance. Journal of Infectious Diseases, 217 (4), p. 622-627. ISSN 0022-1899.
Titre du document
Dramatic changes in malaria population genetic complexity in Dielmo and Ndiop, Senegal, revealed using genomic surveillance
Année de publication
2018
Auteurs
Bei A. K., Niang M., Deme A. B., Daniels R. F., Sarr F. D., Sokhna Cheikh, Talla C., Faye J., Diagne N., Doucoure S., Mboup S., Wirth D. F., Tall A., Ndiaye D., Hartl D. L., Volkman S. K., Toure-Balde A.
Source
Journal of Infectious Diseases, 2018,
217 (4), p. 622-627 ISSN 0022-1899
Dramatic changes in transmission intensity can impact Plasmodium population diversity. Using samples from 2 distant time-points in the Dielmo/Ndiop longitudinal cohorts from Senegal, we applied a molecular barcode tool to detect changes in parasite genotypes and complexity of infection that corresponded to changes in transmission intensity. We observed a striking statistically significant difference in genetic diversity between the 2 parasite populations. Furthermore, we identified a genotype in Dielmo and Ndiop previously observed in Thies, potentially implicating imported malaria. This genetic surveillance study validates the molecular barcode as a tool to assess parasite population diversity changes and track parasite genotypes.
Plan de classement
Entomologie médicale / Parasitologie / Virologie [052]
Description Géographique
SENEGAL ; DIELMO ; NDIOP
Localisation
Fonds IRD [F B010072369]
Identifiant IRD
fdi:010072369
