Yeh S. C. auteur aut IRD Pompon Julien auteur aut IRD text journalArticle eng text/pdf born digital access Mosquito-borne flaviviruses (MBFVs) are a global public health burden. MBFVs have several unique 3UTR structures that inhibit the host RNA decay machinery to produce subgenomic flaviviral RNAs (sfRNAs). Number of sfRNA species and their relative quantities are dependent on the 3UTR tertiary structures and can vary between tissues. Two recent in vivo studies demonstrated that sfRNA enhances mosquito transmission, resulting in increased infection rate of saliva. Transmission efficiency is determined by the immune response. First evidence points to sfRNA interference with the Toll and RNAi immune pathways. However, a more complex picture that includes flexibility in sfRNA production and interaction with immune-related proteins remains to be explored. specialized flavivirus mosquitoes sfRNA innate immunity Xrn1 transmission 052 020 37 3 [6 p.] 2018 1044-5498 https://www.documentation.ird.fr/hor/fdi:010071914 10.1089/dna.2017.4059 1044-5498 [F B010071914] https://www.documentation.ird.fr/hor/fdi:010071914 https://www.documentation.ird.fr/intranet/publi/2018/01/010071914.pdf Accès réservé (Intranet de l'IRD) IRD - Base Horizon / Pleins textes 2018-02-05 2023-07-11 fdi:010071914 fre