%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Garavito, G.
%A Bertani, S.
%A Rincon, J.
%A Maurel, S.
%A Monje, M. C.
%A Landau, I.
%A Valentin, A.
%A Deharo, Eric
%T Blood schizontocidal activity of methylene blue in combination with antimalarials against Plasmodium falciparum
%D 2007
%L fdi:010071566
%G ENG
%J Parasite : Journal de la Société Française de Parasitologie
%@ 1252-607X
%K antimalarials ; Plasmodium ; methylene blue ; drug interactions
%M CC:0002480643-0007
%N 2
%P 135-140
%R 10.1051/parasite/2007142135
%U https://www.documentation.ird.fr/hor/fdi:010071566
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers18-05/010071566.pdf
%V 14
%W Horizon (IRD)
%X Methylene blue IMB) is the oldest synthetic antimalarial. It is not used anymore as antimalarial but should be reconsidered. For this purpose we have measured its impact on both chloroquine sensitive and resistant Plasmodium strains. We showed that around 5 nM of MB were able to inhibit 50 % of the parasite growth in vitro end that late rings and early trophozoites were the most sensitive stages, while early rings, late trophozoites and schizonts were less sensitive. Drug interaction study following fractional inhibitory concentrations (FIC) method showed antagonism with amodiaquine, atovaquone, doxycycline, pyrimethamine; additivity with artemether, chloroquine, mefloquine, primaquine and synergy with quinine. These results confirmed the interest of MB that could be integrated in a new low cost antimalarial combination therapy.
%$ 052