@article{fdi:010071566,
  title = {{B}lood schizontocidal activity of methylene blue in combination with antimalarials against {P}lasmodium falciparum},
  author = {{G}aravito, {G}. and {B}ertani, {S}. and {R}incon, {J}. and {M}aurel, {S}. and {M}onje, {M}. {C}. and {L}andau, {I}. and {V}alentin, {A}. and {D}eharo, {E}ric},
  editor = {},
  language = {{ENG}},
  abstract = {{M}ethylene blue {IMB}) is the oldest synthetic antimalarial. {I}t is not used anymore as antimalarial but should be reconsidered. {F}or this purpose we have measured its impact on both chloroquine sensitive and resistant {P}lasmodium strains. {W}e showed that around 5 n{M} of {MB} were able to inhibit 50 % of the parasite growth in vitro end that late rings and early trophozoites were the most sensitive stages, while early rings, late trophozoites and schizonts were less sensitive. {D}rug interaction study following fractional inhibitory concentrations ({FIC}) method showed antagonism with amodiaquine, atovaquone, doxycycline, pyrimethamine; additivity with artemether, chloroquine, mefloquine, primaquine and synergy with quinine. {T}hese results confirmed the interest of {MB} that could be integrated in a new low cost antimalarial combination therapy.},
  keywords = {antimalarials ; {P}lasmodium ; methylene blue ; drug interactions},
  booktitle = {},
  journal = {{P}arasite : {J}ournal de la {S}oci{\'e}t{\'e} {F}ran{\c{c}}aise de {P}arasitologie},
  volume = {14},
  numero = {2},
  pages = {135--140},
  ISSN = {1252-607{X}},
  year = {2007},
  DOI = {10.1051/parasite/2007142135},
  URL = {https://www.documentation.ird.fr/hor/fdi:010071566},
}