@article{fdi:010071341,
  title = {{C}andidate genes-based investigation of susceptibility to {H}uman {A}frican {T}rypanosomiasis in {C}ote d'{I}voire},
  author = {{A}houty, {B}. and {K}offi, {M}. and {I}lboudo, {H}. and {S}imo, {G}. and {M}atovu, {E}. and {M}ulindwa, {J}. and {H}ertz-{F}owler, {C}. and {B}ucheton, {B}runo and {S}idibe, {I}. and {J}amonneau, {V}incent and {M}ac{L}eod, {A}. and {N}oyes, {H}. and {N}'{G}uetta, {S}. {P}. and {T}rypano{GEN} {R}esearch {G}roup {H}3{A}frica {C}onsortium},
  editor = {},
  language = {{ENG}},
  abstract = {{H}uman {A}frican {T}rypanosomiasis ({HAT}) or sleeping sickness is a {N}eglected {T}ropical {D}isease. {L}ong regarded as an invariably fatal disease, there is increasing evidence that infection by {T}.b. gambiense can result in a wide range of clinical outcomes, including latent infections, which are long lasting infections with no parasites detectable by microscopy. {T}he determinants of this clinical diversity are not well understood but could be due in part to parasite or host genetic diversity in multiple genes, or their interactions. {A} candidate gene association study was conducted in {C}ote d'{I}voire using a case-control design which included a total of 233 subjects (100 active {HAT} cases, 100 controls and 33 latent infections). {A}ll three possible pairwise comparisons between the three phenotypes were tested using 96 {SNP}s in 16 candidate genes ({IL}1, {IL}4, {IL}4{R}, {IL}6, {IL}8, {IL}10, {IL}12, {IL}12{R}, {TNFA}, {INFG}, {MIF}, {APOL}1, {HPR}, {CFH}, {HLA}-{A} and {HLA}-{G}). {D}ata from 77 {SNP}s passed quality control. {T}here were suggestive associations at three loci in {IL}6 and {TNFA} in the comparison between active cases and controls, one {SNP} in each of {APOL}1, {MIF} and {IL}6 in the comparison between latent infections and active cases and seven {SNP} in {IL}4, {HLA}-{G} and {TNFA} between latent infections and controls. {N}o associations remained significant after {B}onferroni correction, but the {B}enjamini {H}ochberg false discovery rate test indicated that there were strong probabilities that at least some of the associations were genuine. {T}he excess of associations with latent infections despite the small number of samples available suggests that these subjects form a distinct genetic cluster different from active {HAT} cases and controls, although no clustering by phenotype was observed by principle component analysis. {T}his underlines the complexity of the interactions existing between host genetic polymorphisms and parasite diversity.},
  keywords = {{COTE} {D}'{IVOIRE}},
  booktitle = {},
  journal = {{PLOS} {N}eglected {T}ropical {D}iseases},
  volume = {11},
  numero = {10},
  pages = {e0005992 [13 p.]},
  ISSN = {1935-2735},
  year = {2017},
  DOI = {10.1371/journal.pntd.0005992},
  URL = {https://www.documentation.ird.fr/hor/fdi:010071341},
}