@article{fdi:010071273,
  title = {{M}odelling dynamic change of malaria transmission in holoendemic setting ({D}ielmo, {S}enegal) using longitudinal measures of antibody prevalence to {P}lasmodium falciparum crude schizonts extract},
  author = {{N}iass, {O}. and {S}aint-{P}ierre, {P}. and {N}iang, {M}. and {D}iop, {F}. and {D}iouf, {B}. and {F}aye, {M}. {M}. and {S}arr, {F}. {D}. and {F}aye, {J}. and {D}iagne, {N}. and {S}okhna, {C}heikh and {T}rape, {J}ean-{F}ran{\c{c}}ois and {P}erraut, {R}. and {T}all, {A}. and {D}iongue, {A}. {K}. and {B}alde, {A}. {T}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {E}valuation of local {P}lasmodium falciparum malaria transmission has been investigated previously using the reversible catalytic model based on prevalence of antibody responses to single antigen to estimate seroconversion rates. {H}igh correlations were observed between seroconversion rates and entomological inoculation rates ({EIR}). {H}owever, in this model, the effects of malaria control interventions and clinical episodes on serological measurements were not assessed. {T}his study monitors the use of antibody responses to {P}. falciparum crude extracts for assessing malaria transmission, compares seroconversion rates estimated from longitudinal data to those derived from cross-sectional surveys and investigates the effects of malaria control interventions on these measures in an area of declining malaria transmission. {I}n addition, the validity of this model was evaluated by comparison with the alternative model. {M}ethods: {F}ive cross-sectional surveys were carried out at the end of the wet season in {D}ielmo, a malaria-endemic {S}enegalese rural area in 2000, 2002, 2008, 2010 and 2012. {A}ntibodies against schizonts crude extract of a local {P}. falciparum strain adapted to culture ({P}f 07/03) were measured by {ELISA}. {A}ge-specific seroprevalence model was used both for cross-sectional surveys and longitudinal data (combined data of all surveys). {R}esults: {A} total of 1504 plasma samples obtained through several years follow-up of 350 subjects was used in this study. {S}eroconversion rates based on {P}. falciparum schizonts crude extract were estimated for each cross-sectional survey and were found strongly correlated with {EIR}. {H}igh variability between {SCR}s from cross-sectional and longitudinal surveys was observed. {I}n longitudinal studies, the alternative catalytic reversible model adjusted better with serological data than the catalytic model. {C}linical malaria attacks and malaria control interventions were found to have significant effect on seroconversion. {D}iscussion: {T}he results of the study suggested that crude extract was a good serological tool that could be used to assess the level of malaria exposure in areas where malaria transmission is declining. {H}owever, additional parameters such as clinical malaria and malaria control interventions must be taken into account for determining serological measurements for more accuracy in transmission assessment.},
  keywords = {{SENEGAL} ; {DIELMO}},
  booktitle = {},
  journal = {{M}alaria {J}ournal},
  volume = {16},
  numero = {},
  pages = {art. 409 [12 p.]},
  ISSN = {1475-2875},
  year = {2017},
  DOI = {10.1186/s12936-017-2052-0},
  URL = {https://www.documentation.ird.fr/hor/fdi:010071273},
}