@article{fdi:010071019,
  title = {{S}hell extracts of the edible mussel and oyster induce an enhancement of the catabolic pathway of human skin fibroblasts, in vitro},
  author = {{L}atire, {T}. and {L}egendre, {F}. and {B}ouyoucef, {M}. and {M}arin, {F}r{\'e}d{\'e}ric and {C}arreiras, {F}. and {R}igot-{J}olivet, {M}. and {L}ebel, {J}. {M}. and {G}alera, {P}. and {S}erpentini, {A}.},
  editor = {},
  language = {{ENG}},
  abstract = {{M}ollusc shells are composed of more than 95% calcium carbonate and less than 5% organic matrix consisting mostly of proteins, glycoproteins and polysaccharides. {I}n this study, we investigated the effects of matrix macromolecular components extracted from the shells of two edible molluscs of economic interest, i.e., the blue mussel {M}ytilus edulis and the {P}acific oyster {C}rassostrea gigas. {T}he potential biological activities of these organic molecules were analysed on human dermal fibroblasts in primary culture. {O}ur results demonstrate that shell extracts of the two studied molluscs modulate the metabolic activities of the cells. {I}n addition, the extracts caused a decrease of type {I} collagen and a concomitant increase of active {MMP}-1, both at the m{RNA} and the protein levels. {T}herefore, our results suggest that shell extracts from {M}. edulis and {C}. gigas contain molecules that promote the catabolic pathway of human dermal fibroblasts. {T}his work emphasises the potential use of these shell matrices in the context of anti-fibrotic strategies, particularly against scleroderma. {M}ore generally, it stresses the usefulness to valorise bivalve shells that are coproducts of shellfish farming activity.},
  keywords = {{B}iological activity ; {E}xtracellular matrix ; {F}ibroblast ; {M}ollusc ; {S}hell matrix},
  booktitle = {},
  journal = {{C}ytotechnology},
  volume = {69},
  numero = {5},
  pages = {815--829},
  ISSN = {0920-9069},
  year = {2017},
  DOI = {10.1007/s10616-017-0096-1},
  URL = {https://www.documentation.ird.fr/hor/fdi:010071019},
}