@article{fdi:010070956,
  title = {{T}he advanced-{D}ia{R}em score improves prediction of diabetes remission 1 year post-{R}oux-en-{Y} gastric bypass},
  author = {{A}ron-{W}isnewsky, {J}. and {S}okolovska, {N}. and {L}iu, {Y}. {J}. and {C}omaneshter, {D}. {S}. and {V}inker, {S}. and {P}echt, {T}. and {P}oitou, {C}. and {O}ppert, {J}. {M}. and {B}ouillot, {J}. {L}. and {G}enser, {L}. and {D}icker, {D}. and {Z}ucker, {J}ean-{D}aniel and {R}udich, {A}. and {C}lement, {K}.},
  editor = {},
  language = {{ENG}},
  abstract = {{A}ims/hypothesis {N}ot all people with type 2 diabetes who undergo bariatric surgery achieve diabetes remission. {T}hus it is critical to develop methods for predicting outcomes that are applicable for clinical practice. {T}he {D}ia{R}em score is relevant for predicting diabetes remission post-{R}oux-en-{Y} gastric bypass ({RYGB}), but it is not accurate for all individuals across the entire spectrum of scores. {W}e aimed to develop an improved scoring system for predicting diabetes remission following {RYGB} (the {A}dvanced-{D}ia{R}em [{A}d-{D}ia{R}em]). {M}ethods {W}e used a retrospective {F}rench cohort (n = 1866) that included 352 individuals with type 2 diabetes followed for 1 year post-{RYGB}. {W}e developed the {A}d-{D}ia{R}emin a test cohort (n = 213) and examined its accuracy in independent cohorts from {F}rance (n = 134) and {I}srael (n = 99). {R}esults {A}dding two clinical variables (diabetes duration and number of glucose-lowering agents) to the original {D}ia{R}em and modifying the penalties for each category led to improved predictive performance for {A}d-{D}ia{R}em. {A}d-{D}ia{R}em displayed improved area under the receiver operating characteristic curve and predictive accuracy compared with {D}ia{R}em (0.911 vs 0.856 and 0.841 vs 0.789, respectively; p = 0.03); thus correcting classification for 8% of those initially misclassified with {D}ia{R}em. {W}ith {A}d-{D}ia{R}em, there were also fewer misclassifications of individuals with mid-range scores. {T}his improved predictive performance was confirmed in independent cohorts. {C}onclusions/interpretation {W}e propose the {A}d-{D}ia{R}em, which includes two additional clinical variables, as an optimised tool with improved accuracy to predict diabetes remission 1 year post-{RYGB}. {T}his tool might be helpful for personalised management of individuals with diabetes when considering bariatric surgery in routine care, ultimately contributing to precision medicine.},
  keywords = {{B}ariatric surgery ; {D}iabetes remission ; {O}bese ; {T}ype 2 diabetesmellitus ; {FRANCE}},
  booktitle = {},
  journal = {{D}iabetologia},
  volume = {60},
  numero = {10},
  pages = {1892--1902},
  ISSN = {0012-186{X}},
  year = {2017},
  DOI = {10.1007/s00125-017-4371-7},
  URL = {https://www.documentation.ird.fr/hor/fdi:010070956},
}