@article{fdi:010070859,
  title = {{E}valuation of two lead malaria transmission blocking vaccine candidate antibodies in natural parasite-vector combinations},
  author = {{B}ompard, {A}. and {D}a, {D}. {F}. and {Y}erbanga, {R}. {S}. and {B}iswas, {S}. and {K}apulu, {M}. and {B}ousema, {T}. and {L}ef{\`e}vre, {T}hierry and {C}ohuet, {A}nna and {C}hurcher, {T}. {S}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}ransmission blocking vaccines ({TBV}) which aim to control malaria by inhibiting human-to-mosquito transmission show considerable promise though their utility against naturally circulating parasites remains unknown. {T}he efficacy of two lead candidates targeting {P}fs25 and {P}fs230 antigens to prevent onwards transmission of naturally occurring parasites to a local mosquito strain is assessed using direct membrane feeding assays and murine antibodies in {B}urkina {F}aso. {T}he transmission blocking activity of both candidates depends on the level of parasite exposure (as assessed by the mean number of oocysts in control mosquitoes) and antibody titers. {A} mathematical framework is devised to allow the efficacy of different candidates to be directly compared and determine the minimal antibody titers required to halt transmission in different settings. {T}he increased efficacy with diminishing parasite exposure indicates that the efficacy of vaccines targeting either {P}fs25 or {P}fs230 may increase as malaria transmission declines. {T}his has important implications for late-stage candidate selection and assessing how they can support the drive for malaria elimination.},
  keywords = {},
  booktitle = {},
  journal = {{S}cientific {R}eports - {N}ature},
  volume = {7},
  numero = {1},
  pages = {art. 6766 [9 p.]},
  ISSN = {2045-2322},
  year = {2017},
  DOI = {10.1038/s41598-017-06130-1},
  URL = {https://www.documentation.ird.fr/hor/fdi:010070859},
}