@article{fdi:010070346,
  title = {{M}alaria in {D}ielmo, a {S}enegal village : is its elimination possible after seven years of implementation of long-lasting insecticide-treated nets ?},
  author = {{W}otodjo, {A}. {N}. and {D}oucoure, {S}. and {G}audart, {J}. and {D}iagne, {N}. and {S}arr, {F}. {D}. and {F}aye, {N}. and {T}all, {A}. and {R}aoult, {D}. and {S}okhna, {C}heikh},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground {T}he malaria burden has decreased significantly in recent years in {A}frica through the widespread use of artemisinin-based combination therapy ({ACT}) and long-lasting insectici-detreated nets ({LLIN}s). {H}owever, the occurrence of malaria resurgences, the loss of immunity of exposed populations constitute among other factors, serious concerns about the future of malaria elimination efforts. {T}his study investigated the evolution of malaria morbidity in {D}ielmo ({S}enegal) before and after the implementation of {LLIN}s. {M}ethods {A} longitudinal study was carried out in {D}ielmo over eight years, from {J}uly 2007 to {J}uly 2015. {I}n {J}uly 2008, {LLIN}s were offered to all villagers, and in {J}uly 2011 and {A}ugust 2014 the {LLIN}s were renewed. {A} survey on {LLIN}s use was done each quarter of the year. {T}hick smears stained with {G}iemsa, a rapid diagnostic test ({RDT}) and quantitative polymerase chain reaction ({PCR}) methods were performed for all cases of fever to assess malaria clinical attacks. {M}alaria cases were treated with {ACT} since {J}une 2006. {R}esults {M}alaria morbidity has decreased significantly since the implementation of {LLIN}s in {D}ielmo, together with {ACT}. {H}owever, malaria resurgences have occurred twice during the seven years of {LLIN}s use. {T}hese resurgences occurred the first time during the third year after the introduction of {LLIN}s (a{IRR} (adjusted incidence-rate ratio) [95% {CI}] = 5.90 [3.53; 9.88] p< 0.001) and a second time during the third year after the renewal of {LLIN}s (a{IRR} [95% {CI}] = 5.60 [3.34; 9.39] p<0.001). {S}ixty-nine percent (69%) of the nets tested for their long-lasting insecticidal activity remained effective after 3 years of use. {C}onclusion {G}ood management of malaria cases by the use of {ACT} as first-line treatment against malaria in addition to the use of {LLIN}shas significantly reduced malaria in {D}ielmo and allowed to reach the phase of pre-elimination of the disease. {H}owever, the occurrence of malaria resurgences raised serious concerns about malaria elimination, which would require additional tools in this village.},
  keywords = {{SENEGAL}},
  booktitle = {},
  journal = {{P}los {O}ne},
  volume = {12},
  numero = {7},
  pages = {e0179528 [13 p.]},
  ISSN = {1932-6203},
  year = {2017},
  DOI = {10.1371/journal.pone.0179528},
  URL = {https://www.documentation.ird.fr/hor/fdi:010070346},
}