Delory T. auteur aut IRD Ngo-Giang-Huong Nicole auteur aut IRD Rangdaeng S. auteur aut IRD Chotivanich N. auteur aut IRD Limtrakul A. auteur aut IRD Putiyanun C. auteur aut IRD Suriyachai P. auteur aut IRD Matanasarawut W. auteur aut IRD Jarupanich T. auteur aut IRD Liampongsabuddhi P. auteur aut IRD Heard I. auteur aut IRD Jourdain Gonzague auteur aut IRD Lallemant Marc auteur aut IRD Le Coeur S. auteur aut IRD PapilloV Study Group auteur aut IRD text journalArticle eng text/pdf born digital access Objectives: To estimate the prevalence and factors associated with Human Papillomavirus (HPV) infection, HPV genotypes and cytological/histological high-grade (HSIL+/ CIN2+) lesions. Methods: We conducted a cross-sectional study within a prospective cohort of HIV-infected women on combination antiretroviral therapy (cART). Cervical specimens were collected for cytology and HPV genotyping (Papillocheck (R)). Any women with High-Risk-HPV (HR-HPV), and/or potentially HR-HPV (pHR-HPV) and/or ASC-US or higher (ASC-US+) lesions were referred for colposcopy. Factors associated with HR-HPV infection and with HSIL+/CIN2+ lesions were investigated using mixed-effects logistic regression models. Results: 829 women were enrolled: median age 40.4 years, on cART for a median of 6.9 years, median CD4 cell-count 536 cells/mm3, and 788 (96%) with HIV-viral load< 50copies/mL. Of 214 (26%) infected with HPV: 159 (19%) had >= 1 HR-HPV, of whom 38 (5%) HPV52, 22 (3%) HPV16, 9 (1%) HPV18; 21 (3%) had pHR-HPV, 34 (4%) low risk-HPV infection, and 56 (26%) had multiple genotypes. Younger age, low CD4 cell-counts and low education were independently associated with HR-HPV infection. 72 women (9%) had ASC-US+ and 28 (3%) HSIL+/CIN2+ lesions. HR-HPV infection was independently associated with HSIL+/CIN2+ lesions. Conclusion: The prevalence of HPV infection and of cervical lesions was low. The HPV genotype distribution supports the use of 9-valent vaccine in Thailand. specialized HPV HIV Women Thailand Cervical lesions Cancer Antiretroviral therapy Cross-sectional study THAILANDE 050 052 74 5 501-511 2017 0163-4453 https://www.documentation.ird.fr/hor/fdi:010069963 10.1016/j.jinf.2017.02.007 0163-4453 [F B010069963] https://www.documentation.ird.fr/hor/fdi:010069963 https://www.documentation.ird.fr/intranet/publi/2017/05/010069963.pdf Accès réservé (Intranet de l'IRD) IRD - Base Horizon / Pleins textes 2017-06-01 2023-07-11 fdi:010069963 fre