Boufridi A. auteur aut IRD Lachkar D. auteur aut IRD Erpenbeck D. auteur aut IRD Beniddir M.A. auteur aut IRD Evanno L. auteur aut IRD Petek Sylvain auteur aut IRD Debitus Cécile auteur aut IRD Poupon E. auteur aut IRD text journalArticle eng text/pdf reformatted digital access Dactylospongia metachromia and Dactylospongia elegans collected from French Polynesia were studied with a particular focus on the variation of the diastereomeric ratio between ilimaquinone (4) and 5-epi-ilimaquinone (5). More than 100 samples, covering an area of 4100km2, were studied to try to clarify this intriguing issue. Nuclear magnetic resonance appeared as the non-destructive, straightforward technique of choice for a relative quantitative study. A random distribution, unique at that point in nature, is observed and leads to biosynthetic considerations. Biological evaluation of both compounds was also performed and showed moderate discrepancies in cytotoxicity and apoptosis induction. POLYNESIE FRANCAISE PACIFIQUE 035 70 6 743-750 2017 0004-9425 https://www.documentation.ird.fr/hor/fdi:010069903 10.1071/CH16455 0004-9425 [F B010069903] https://www.documentation.ird.fr/hor/fdi:010069903 https://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers17-05/010069903.pdf IRD - Base Horizon / Pleins textes 2017-05-31 2023-07-11 fdi:010069903 fre