@article{fdi:010069611,
  title = {{G}enetic diversity and population structure of {M}ycobacterium marinum : new insights into host and environmental specificities},
  author = {{B}routin, {V}. and {B}anuls, {A}nne-{L}aure and {A}ubry, {A}. and {K}eck, {N}. and {C}hoisy, {M}arc and {B}ernardet, {J}. {F}. and {M}ichel, {C}. and {R}aymond, {J}. {C}. and {L}ibert, {C}. and {B}arnaud, {A}. and {S}tragier, {P}. and {P}ortaels, {F}. and {T}erru, {D}. and {B}elon, {C}. and {D}ereure, {O}. and {G}utierrez, {C}. and {B}oschiroli, {M}. {L}. and {V}an {D}e {P}erre, {P}. and {C}ambau, {E}. and {G}odreuil, {S}.},
  editor = {},
  language = {{ENG}},
  abstract = {{M}ycobacterium marinum causes a systemic tuberculosis-like disease in fish and skin infections in humans that can spread to deeper structures, resulting in tenosynovitis, arthritis, and osteomyelitis. {H}owever, little information is available concerning (i) the intraspecific genetic diversity of {M}. marinum isolated from humans and animals; (ii) {M}. marinum genotype circulation in the different ecosystems, and (iii) the link between {M}. marinum genetic diversity and hosts (humans and fish). {H}ere, we conducted a genetic study on 89 {M}. marinum isolates from humans (n = 68) and fish (n = 21) by using mycobacterial interspersed repetitive units-variable number of tandem repeats ({MIRU}-{VNTR}) typing. {T}he results show that the {M}. marinum population is genetically structured not only according to the host but also according to the ecosystem as well as to tissue tropism in humans. {T}his suggests the existence of different genetic pools in the function of the biological and ecological compartments. {M}oreover, the presence of only certain {M}. marinum genotypes in humans suggests a different zoonotic potential of the {M}. marinum genotypes. {C}onsidering that the infection is linked to aquarium activity, a significant genetic difference was also detected when the human tissue tropism of {M}. marinum was taken into consideration, with a higher genetic polymorphism in strains isolated from patients with cutaneous forms than from individuals with deeper-structure infection. {I}t appears that only few genotypes can produce deeper infections in humans, suggesting that the immune system might play a filtering role.},
  keywords = {},
  booktitle = {},
  journal = {{J}ournal of {C}linical {M}icrobiology},
  volume = {50},
  numero = {11},
  pages = {3627--3634},
  ISSN = {0095-1137},
  year = {2012},
  URL = {https://www.documentation.ird.fr/hor/fdi:010069611},
}