@article{fdi:010069412,
  title = {{P}hyloepidemiological analysis reveals that viral divergence led to the paucity of simian immunodeficiency virus sivmus/gsn/mon infections in wild populations},
  author = {{S}chmidt, {F}. and {L}i{\'e}geois, {F}lorian and {G}reenwood, {E}. {J}. {D}. and {L}e{B}reton, {M}. and {L}ester, {J}. and {D}eleplancque, {L}. and {P}eeters, {M}artine and {A}ghokeng {F}obang, {A}velin and {T}amoufe, {U}. and {D}iffo, {J}. {L}. {D}. and {T}akuo, {J}. {M}. and {W}olfe, {N}. {D}. and {L}eroy, {E}ric and {R}ouet, {F}. and {H}eeney, {J}. {L}.},
  editor = {},
  language = {{ENG}},
  abstract = {{H}uman immunodeficiency virus type 1 ({HIV}-1) is the result of crossspecies transmission of simian immunodeficiency virus from chimpanzees ({SIV}cpz). {SIV}cpz is a chimeric virus which shares common ancestors with viruses infecting redcapped mangabeys and a subset of guenon species. {T}he epidemiology of {SIV} infection in hominoids is characterized by low prevalences and an uneven geographic distribution. {S}urveys in {C}ameroon indicated that two closely related members of the guenon species subset, mustached guenons and greater spot-nosed guenons, infected with {SIV}mus and {SIV}gsn, respectively, also have low rates of {SIV} infections in their populations. {C}ompared to that for other monkeys, including red-capped mangabeys and closely related guenon species, such an epidemiology is unusual. {B}y intensifying sampling of geographically distinct populations of mustached and greater spot-nosed guenons in {G}abon and including large sample sets of mona guenons from {C}ameroon, we add strong support to the hypothesis that the paucity of {SIV} infections in wild populations is a general feature of this monophyletic group of viruses. {F}urthermore, comparative phylogenetic analysis reveals that this phenotype is a feature of this group of viruses infecting phylogenetically disparate hosts, suggesting that this epidemiological phenotype results from infection with these {HIV}-1related viruses rather than from a common host factor. {T}hus, these {HIV}-1-related viruses, i.e., {SIV}cpz and the guenon viruses which share an ancestor with part of the {SIV}cpz genome, have an epidemiology distinct from that found for {SIV}s in other {A}frican primate species. {IMPORTANCE} {S}table virus-host relationships are established over multiple generations. {T}he prevalence of viral infections in any given host is determined by various factors. {S}table virus-host relationships of viruses that are able to cause persistent infections and exist with high incidences of infection are generally characterized by a lack of morbidity prior to host reproduction. {S}uch is the case for cytomegalovirus ({CMV}) and {E}pstein-{B}arr virus ({EBV}) infections of humans. {SIV} infections of most {A}frican primate species also satisfy these criteria, with these infections found at a high prevalence and with rare cases of clinical disease. {I}n contrast, {SIV}cpz, the ancestor of {HIV}-1, has a different epidemiology, and it has been reported that infected animals suffer from an {AIDS}-like disease in the wild. {H}ere we conclusively demonstrate that viruses which are closely related to {SIV}cpz and infect a subset of guenon monkeys show an epidemiology resembling that of {SIV}cpz.},
  keywords = {{C}ameroon ; {G}abon ; {SIV} prevalence ; bushmeat ; guenon ; lentivirus ; nonhuman ; primate ; simian immunodeficiency virus ; {CAMEROUN} ; {GABON}},
  booktitle = {},
  journal = {{J}ournal of {V}irology},
  volume = {91},
  numero = {6},
  pages = {e01884--16 [8 p.]},
  ISSN = {0022-538{X}},
  year = {2017},
  DOI = {10.1128/jvi.01884-16},
  URL = {https://www.documentation.ird.fr/hor/fdi:010069412},
}