@article{fdi:010069363,
  title = {{U}se of an {A}nopheles salivary biomarker to assess malaria transmission risk along the {T}hailand-{M}yanmar border},
  author = {{Y}a-{U}mphan, {P}. and {C}erqueira, {D}. and {P}arker, {D}. {M}. and {C}ottrell, {G}illes and {P}oinsignon, {A}nne and {R}emou{\'e}, {F}ranck and {B}rengues, {C}{\'e}cile and {C}hareonviriyaphap, {T}. and {N}osten, {F}. and {C}orbel, {V}incent},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground. {T}he modalities of malaria transmission along the {T}hailand-{M}yanmar border are poorly understood. {H}ere we address the relevance of using a specific {A}nopheles salivary biomarker to measure the risk among humans of exposure to {A}nopheles bites. {M}ethods. {S}erologic surveys were conducted from {M}ay 2013 to {D}ecember 2014 in 4 sentinel villages. {M}ore than 9400 blood specimens were collected in filter papers from all inhabitants at baseline and then every 3 months thereafter, for up to 18 months, for analysis by enzyme-linked immunosorbent assay. {T}he relationship between the intensity of the human antibody response and entomological indicators of transmission (human biting rates and entomological inoculation rates [{EIR}s]) was studied using a multivariate 3-level mixed model analysis. {H}eat maps for human immunoglobulin {G} ({I}g{G}) responses for each village and survey time point were created using {QGIS} 2.4. {R}esults. {T}he levels of {I}g{G} response among participants varied significantly according to village, season, and age ({P} <.001) and were positively associated with the abundance of total {A}nopheles species and primary malaria vectors and the {EIR} ({P} <.001). {S}patial clusters of high-{I}g{G} responders were identified across space and time within study villages. {C}onclusions. {T}he g{SG}6-{P}1 biomarker has great potential to address the risk of transmission along the {T}hailand-{M}yanmar border and represents a promising tool to guide malaria interventions.},
  keywords = {{T}hailand-{M}yanmar border ; malaria vectors ; transmission ; human antibody ; response ; {S}alivary {B}iomarker ; g{SG}6-{P}1 ; {THAILANDE} ; {MYANMAR}},
  booktitle = {},
  journal = {{J}ournal of {I}nfectious {D}iseases},
  volume = {215},
  numero = {3},
  pages = {396--404},
  ISSN = {0022-1899},
  year = {2017},
  DOI = {10.1093/infdis/jiw543},
  URL = {https://www.documentation.ird.fr/hor/fdi:010069363},
}