%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A d'Almeida, T. C.
%A Sadissou, I.
%A Milet, Jacqueline
%A Cottrell, Gilles
%A Mondiere, A.
%A Avokpaho, E.
%A Gineau, L.
%A Sabbagh, A.
%A Massougbodji, A.
%A Moutairou, K.
%A Donadi, E. A.
%A Favier, B.
%A Carosella, E.
%A Moreau, P.
%A Rouas-Freiss, N.
%A Courtin, David
%A Garcia, André
%T Soluble human leukocyte antigen -G during pregnancy and infancy in Benin : mother/child resemblance and association with the risk of malaria infection and low birth weight
%D 2017
%L fdi:010069310
%G ENG
%J Plos One
%@ 1932-6203
%K BENIN
%M ISI:000393700100024
%N 2
%P e0171117 [17 ]
%R 10.1371/journal.pone.0171117
%U https://www.documentation.ird.fr/hor/fdi:010069310
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers17-03/010069310.pdf
%V 12
%W Horizon (IRD)
%X Human leukocyte antigen (HLA) G is a tolerogenic molecule involved in the maternal-fetal immune tolerance phenomenon. Its expression during some infectious diseases leading to immune evasion has been established. A first study conducted in Benin has shown that the production of soluble HLA-G (sHLA-G) during the first months of life is strongly correlated with the maternal level at delivery and associated with low birth weight and malaria. However sHLA-G measurements during pregnancy were not available for mothers and furthermore, to date the evolution of sHLA-G in pregnancy is not documented in African populations. To extend these previous findings, between January 2010 and June 2013, 400 pregnant women of a malaria preventive trial and their newborns were followed up in Benin until the age of 2 years. Soluble HLA-G was measured 3 times during pregnancy and repeatedly during the 2 years follow-up to explore how sHLA-G evolved and the factors associated. During pregnancy, plasma levels of sHLA-G remained stable and increased significantly at delivery (p<0.001). Multigravid women seemed to have the highest levels (p = 0.039). In infants, the level was highest in cord blood and decreased before stabilizing after 18 months (p<0.001). For children, a high level of sHLA-G was associated with malaria infection during the follow-up (p = 0.02) and low birth weight (p = 0.06). The mean level of sHLA-G during infancy was strongly correlated with the mother's level during pregnancy (<0.001), and not only at delivery. Moreover, mothers with placental malaria infection had a higher probability of giving birth to a child with a high level of sHLA-g (p = 0.006). High sHLA-G levels during pregnancy might be associated with immune tolerance related to placental malaria. Further studies are needed but this study provides a first insight concerning the potential role of sHLA-G as a biomarker of weakness for newborns and infants.
%$ 050