@article{fdi:010069310,
  title = {{S}oluble human leukocyte antigen -{G} during pregnancy and infancy in {B}enin : mother/child resemblance and association with the risk of malaria infection and low birth weight},
  author = {d'{A}lmeida, {T}. {C}. and {S}adissou, {I}. and {M}ilet, {J}acqueline and {C}ottrell, {G}illes and {M}ondiere, {A}. and {A}vokpaho, {E}. and {G}ineau, {L}. and {S}abbagh, {A}. and {M}assougbodji, {A}. and {M}outairou, {K}. and {D}onadi, {E}. {A}. and {F}avier, {B}. and {C}arosella, {E}. and {M}oreau, {P}. and {R}ouas-{F}reiss, {N}. and {C}ourtin, {D}avid and {G}arcia, {A}ndr{\'e}},
  editor = {},
  language = {{ENG}},
  abstract = {{H}uman leukocyte antigen ({HLA}) {G} is a tolerogenic molecule involved in the maternal-fetal immune tolerance phenomenon. {I}ts expression during some infectious diseases leading to immune evasion has been established. {A} first study conducted in {B}enin has shown that the production of soluble {HLA}-{G} (s{HLA}-{G}) during the first months of life is strongly correlated with the maternal level at delivery and associated with low birth weight and malaria. {H}owever s{HLA}-{G} measurements during pregnancy were not available for mothers and furthermore, to date the evolution of s{HLA}-{G} in pregnancy is not documented in {A}frican populations. {T}o extend these previous findings, between {J}anuary 2010 and {J}une 2013, 400 pregnant women of a malaria preventive trial and their newborns were followed up in {B}enin until the age of 2 years. {S}oluble {HLA}-{G} was measured 3 times during pregnancy and repeatedly during the 2 years follow-up to explore how s{HLA}-{G} evolved and the factors associated. {D}uring pregnancy, plasma levels of s{HLA}-{G} remained stable and increased significantly at delivery (p<0.001). {M}ultigravid women seemed to have the highest levels (p = 0.039). {I}n infants, the level was highest in cord blood and decreased before stabilizing after 18 months (p<0.001). {F}or children, a high level of s{HLA}-{G} was associated with malaria infection during the follow-up (p = 0.02) and low birth weight (p = 0.06). {T}he mean level of s{HLA}-{G} during infancy was strongly correlated with the mother's level during pregnancy (<0.001), and not only at delivery. {M}oreover, mothers with placental malaria infection had a higher probability of giving birth to a child with a high level of s{HLA}-g (p = 0.006). {H}igh s{HLA}-{G} levels during pregnancy might be associated with immune tolerance related to placental malaria. {F}urther studies are needed but this study provides a first insight concerning the potential role of s{HLA}-{G} as a biomarker of weakness for newborns and infants.},
  keywords = {{BENIN}},
  booktitle = {},
  journal = {{P}los {O}ne},
  volume = {12},
  numero = {2},
  pages = {e0171117 [17 p.]},
  ISSN = {1932-6203},
  year = {2017},
  DOI = {10.1371/journal.pone.0171117},
  URL = {https://www.documentation.ird.fr/hor/fdi:010069310},
}