@article{fdi:010069206,
  title = {{A} mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis},
  author = {{K}hor, {C}. {C}. and {C}hapman, {S}. {J}. and {V}annberg, {F}. {O}. and {D}unne, {A}. and {M}urphy, {C}. and {L}ing, {E}. {Y}. and {F}rodsham, {A}. {J}. and {W}alley, {A}. {J}. and {K}yrieleis, {O}. and {K}han, {A}. and {A}ucan, {C}. and {S}egal, {S}. and {M}oore, {C}. {E}. and {K}nox, {K}. and {C}ampbell, {S}. {J}. and {L}ienhardt, {C}hristian and {S}cott, {A}. and {A}aby, {P}. and {S}ow, {O}. {Y}. and {G}rignani, {R}. {T}. and {S}illah, {J}. and {S}irugo, {G}. and {P}eshu, {N}. and {W}illiams, {T}. {N}. and {M}aitland, {K}. and {D}avies, {R}. {J}. {O}. and {K}wiatkowski, {D}. {P}. and {D}ay, {N}. {P}. and {Y}ala, {D}. and {C}rook, {D}. {W}. and {M}arsh, {K}. and {B}erkley, {J}. {A}. and {O}' {N}eill, {L}.{A}.{J}. and {H}ill, {A}. {V}. {S}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}oll-like receptors ({TLR}s) and members of their signaling pathway are important in the initiation of the innate immune response to a wide variety of pathogens(1-3). {T}he adaptor protein {M}al (also known as {TIRAP}), encoded by {TIRAP} ({MIM} 606252), mediates downstream signaling of {TLR}2 and {TLR}4 (refs. 4-6). {W}e report a case-control study of 6,106 individuals from the {UK}, {V}ietnam and several {A}frican countries with invasive pneumococcal disease, bacteremia, malaria and tuberculosis. {W}e genotyped 33 {SNP}s, including rs8177374, which encodes a leucine substitution at {S}er180 of {M}al. {W}e found that heterozygous carriage of this variant associated independently with all four infectious diseases in the different study populations. {C}ombining the study groups, we found substantial support for a protective effect of {S}180{L} heterozygosity against these infectious diseases ({N} = 6,106; overall {P} = 9.6 x 10(-8)). {W}e found that the {M}al {S}180{L} variant attenuated {TLR}2 signal transduction.},
  keywords = {{ALGERIE} ; {KENYA} ; {GAMBIE} ; {GUINEE} ; {GUINEE} {BISSAU} ; {VIET} {NAM} ; {ROYAUME} {UNI}},
  booktitle = {},
  journal = {{N}ature {G}enetics},
  volume = {39},
  numero = {4},
  pages = {523--528},
  ISSN = {1061-4036},
  year = {2007},
  DOI = {10.1038/ng1976},
  URL = {https://www.documentation.ird.fr/hor/fdi:010069206},
}