@article{fdi:010069112,
  title = {{T}ropheryma whipplei bacteremia during fever in rural {W}est {A}frica},
  author = {{F}enollar, {F}. and {M}ediannikov, {O}leg and {S}ocolovschi, {C}. and {B}assene, {H}. and {D}iatta, {G}. and {R}ichet, {H}. and {T}all, {A}. and {S}okhna, {C}heikh and {T}rape, {J}ean-{F}rancois and {R}aoult, {D}idier},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground. {T}ropheryma whipplei not only causes {W}hipple disease but also is an emerging pathogen associated with gastroenteritis and pneumonia that is commonly detected in stool samples in rural {W}est {A}frica. {W}e investigated the role of {T}. whipplei in febrile patients from rural {S}enegal who had a negative test result for malaria. {M}ethods. {F}rom {N}ovember 2008 through {J}uly 2009, we conducted a prospective study in 2 {S}enegalese villages; 204 blood specimens from febrile patients were collected. {DNA} extraction of whole-blood samples collected by finger pricks with a lancet stick was performed in {S}enegal; elution and quantitative polymerase chain reaction assays for {T}. whipplei were performed in {F}rance. {I}n {A}pril 2009, we conducted a screening to look for the presence of {T}. whipplei in the saliva and stools of the overall population. {B}lood from {F}rench patients with chronic {T}. whipplei in stool samples was also analyzed. {R}esults. {T}he presence of {T}. whipplei {DNA} was detected in blood from 13 (6.4%) of 204 tested patients, mostly in children and in {D}ecember and {J}anuary. {N}one of the {F}rench carriers tested positive. {T}he patients with {T}. whipplei bacteremia presented with fever (13 patients), cough (10), thirst (8), fatigue (7), rhinorrhea (6), and sleep disorders (5). {C}ough and sleep disorders were significantly more frequent in febrile carriers than in the 191 febrile episodes without {T}. whipplei bacteremia ({P} = .002 and .005, respectively). {N}o correlation was observed between the presence of {T}. whipplei in the stools and saliva and bacteremia. {C}onclusions. {O}ur findings suggest that {T}. whipplei is an agent of unexplained cold season fever with cough in rural {W}est {A}frica.},
  keywords = {{AFRIQUE} {DE} {L}'{OUEST}},
  booktitle = {},
  journal = {{C}linical {I}nfectious {D}iseases},
  volume = {51},
  numero = {5},
  pages = {515--521},
  ISSN = {1058-4838},
  year = {2010},
  DOI = {10.1086/655677},
  URL = {https://www.documentation.ird.fr/hor/fdi:010069112},
}