@article{fdi:010068924, title = {{M}ight interspecific interactions between pathogens drive host evolution ? {T}he case of {P}lasmodium species and {D}uffy-negativity in human populations}, author = {{R}oche, {B}enjamin and {R}ougeron, {V}. and {Q}uintana-{M}urci, {L}. and {R}enaud, {F}. and {A}bbate, {J}. {L}. and {P}rugnolle, {F}ranck}, editor = {}, language = {{ENG}}, abstract = {{M}alarial infections have long been recognized as a driver of human evolution, as demonstrated by the influence of {P}lasmodium falciparum on sickle-cell anemia persistence. {D}uffy-negativity is another blood disorder thought to have been selected because it confers nearly complete resistance against {P}lasmodium vivax infection. {R}ecent evidence suggests that the benefits of being {D}uffy negative cannot be expected to play a strong selective pressure on humans, whereas its costs cannot be considered as negligible. {H}ere, we suggest that the cross-talk between {P}. falciparum and {P}. vivax in coinfected children could represent the most parsimonious explanation of the frequency of {D}uffy-negativity. {W}e discuss how this new hypothesis could be tested and call for a reconsideration of the evolution of the {D}uffy-negative group.}, keywords = {{AFRIQUE} {SUBSAHARIENNE}}, booktitle = {}, journal = {{T}rends in {P}arasitology}, volume = {33}, numero = {1}, pages = {21--29}, ISSN = {1471-4922}, year = {2017}, DOI = {10.1016/j.pt.2016.09.010}, URL = {https://www.documentation.ird.fr/hor/fdi:010068924}, }